Matrix vesicle enzyme activity in endosteal bone following implantation of bonding and non.‐bonding implant materials

T. S. Marshall, Z. Schwartz, L. D. Swain, D. Amir, J. Sela, U. Gross, C. Muller‐mai, B. D. Boyan

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The effect of bone bonding (KGy‐Cera) and non‐bone bonding (KGy‐213) implant materials on primary mineralization was examined in endosteal bone repair following marrow ablation. Comparisons were made to determine implant effect on concentration and biochemical parameters of matrix vesicles, as contrasted to vesicles in normal bone healing. Matrix vesicle number was determined by high‐resolution computerized morphometric analysis, and implant effect on the specific activity of alkaline phosphatase and phospholipase AI was measured. Bone responses differed according to the composition of the implant material. The bone bonding implant in this study stimulated matrix vesicle formation, alkaline phosphatase specific activity, and, to a lesser extent, phospholipase A, activity. The effect of the non‐bonding implant on healing bone was of suppression of enzyme specific activities and reduced matrix vesicle production. The results indicate that the bone bonding implant material (KGy‐Cera) promotes the initiation of primary mineralization, whereas failure of the KGy‐213 to bond may be related to toxic materials that leach from the implant and inhibit the normal sequence of events in the mineralization cascade. The results also demonstrate that the implant materials alter the healing process distal to the injury site. Changes observed in the contralateral control limb mimic the changes observed in the injured limb, but at lower magnitude.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalClinical oral implants research
Volume2
Issue number3
DOIs
Publication statusPublished - Jul 1991

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Keywords

  • alkaline phosphatase
  • bone healing
  • calcification
  • ceramic implants
  • matrix vesicles
  • morphometric analysis
  • phospholipase A

ASJC Scopus subject areas

  • Oral Surgery

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