Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus)

Laren Narapareddy, Derek E. Wildman, Don L. Armstrong, Amy Weckle, Aleeca F. Bell, Crystal L. Patil, Suzette D. Tardif, Corinna N. Ross, Julienne N. Rutherford

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation of glycolytic and lipid metabolic processes pathways.

Original languageEnglish (US)
Article numbere23101
JournalAmerican Journal of Primatology
Volume82
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • developmental programming
  • epigenetics
  • maternal metabolism
  • non-human primate
  • obesity

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

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