Maternal vitamin D status has no effect on the ontogeny of calcium-binding proteins in the duodenum, kidney and cerebellum of fetal mice

D. R. Shamley, R. Buffenstein, G. Veale, J. M. Pettifor

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The effects of vitamin D3 deficiency on the ontogeny of calcium-binding proteins (CaBPs) and the vitamin D receptor in the duodenum, kidney and cerebellum of the mouse were examined. Maternal vitamin D status did not affect the time of appearance of the fetal 28 kDa CaBP (CaBP-D(28k)) in the cerebellum, kidney and duodenum, and the 9 kDa CaBP (CaBP-D(9k)) in the intestine and kidney. Vitamin D receptor was undetectable in all fetal tissues, regardless of maternal vitamin D status, at all stages of gestation examined. Thus it appears that maternal vitamin D status does not affect the ontogeny of CaBP-D(9k) or CaBP-D(28k) in the mouse fetus. The factors that influence the appearance of calbindins in the fetus are unclear.

Original languageEnglish (US)
Pages (from-to)473-478
Number of pages6
JournalJournal of Endocrinology
Volume139
Issue number3
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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