Maternal nutrition and metabolic control of pregnancy

Michael L. Power, Suzette D. Tardif

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

A successful human pregnancy follows a chancy path from fertilization to implantation, through an extended period of placental and fetal growth, to a period of fetal organ maturation that corresponds to a change from uterine quiescence to coordinated uterine contractions, and finally to cervical dilation and parturition. The fate of a fertilized human ovum is far from secure (Figure 3.1). It is estimated that one-third to one-half of human conceptuses either do not implant or are lost shortly after implantation. Among those fertilized ova that successfully implant, as many as one in five succumb before delivery. Even in developed nations, of those fetuses that are delivered, 10% are preterm, 5% are small for their gestational age, and 3% have one or more severe congenital defects (Keen et al., 2003). A significant proportion of human morbidity and mortality, from neonates to adults, may be attributable to events in utero. Preterm birth and intrauterine growth restriction (IUGR) are significant sources of neonatal morbidity and mortality. In 1947, Eastman (1947) declared, ‘Only when the factors underlying prematurity are completely understood can any intelligent attempt at prevention be made.’ After considerable research effort since then, our understanding of the causes of preterm labor still is far from complete, and the rate of premature labor and birth has not declined (Goldenberg et al., 2003).

Original languageEnglish (US)
Title of host publicationBirth, Distress and Disease: Placental-Brain Interactions
PublisherCambridge University Press
Pages88-113
Number of pages26
Volume9780521831482
ISBN (Print)9780511545658, 0521831482, 9780521831482
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Mothers
Pregnancy
Premature Obstetric Labor
Zygote
Premature Birth
Morbidity
Uterine Contraction
Infant Mortality
Fetal Development
Developed Countries
Fertilization
Gestational Age
Dilatation
Fetus
Parturition
Mortality
Growth
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Power, M. L., & Tardif, S. D. (2005). Maternal nutrition and metabolic control of pregnancy. In Birth, Distress and Disease: Placental-Brain Interactions (Vol. 9780521831482, pp. 88-113). Cambridge University Press. https://doi.org/10.1017/CBO9780511545658.005

Maternal nutrition and metabolic control of pregnancy. / Power, Michael L.; Tardif, Suzette D.

Birth, Distress and Disease: Placental-Brain Interactions. Vol. 9780521831482 Cambridge University Press, 2005. p. 88-113.

Research output: Chapter in Book/Report/Conference proceedingChapter

Power, ML & Tardif, SD 2005, Maternal nutrition and metabolic control of pregnancy. in Birth, Distress and Disease: Placental-Brain Interactions. vol. 9780521831482, Cambridge University Press, pp. 88-113. https://doi.org/10.1017/CBO9780511545658.005
Power ML, Tardif SD. Maternal nutrition and metabolic control of pregnancy. In Birth, Distress and Disease: Placental-Brain Interactions. Vol. 9780521831482. Cambridge University Press. 2005. p. 88-113 https://doi.org/10.1017/CBO9780511545658.005
Power, Michael L. ; Tardif, Suzette D. / Maternal nutrition and metabolic control of pregnancy. Birth, Distress and Disease: Placental-Brain Interactions. Vol. 9780521831482 Cambridge University Press, 2005. pp. 88-113
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