Maternal Nutrient Restriction Upregulates Growth Signaling Pathways in the Cotyledonary Artery of Cow Placentomes

M. J. Zhu, M. Du, B. W. Hess, W. J. Means, P. W. Nathanielsz, S. P. Ford

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

This study evaluated the role of MAPK/ERK1/2 and/or PI3-K/Akt signaling pathways in modulating bovine placentomal vascularity in response to maternal nutrient restriction. Beef cows were randomly assigned to control fed (Control, n = 15, 100% of requirements) or nutrient restricted (NR, n = 15, 50% requirements) diets from day 30 to day 125 of gestation. Ten cows from each dietary group were necropsied on day 125 (∼45% gestation), and the remaining cows in each diet group were then fed control diets and necropsied on day 250 (∼90% gestation). At day 125 of gestation, NR cows exhibited increased (P = 0.06) COT vascularity, improved (P < 0.05) placentome efficiency (fetal weight/placentomal weight), and increased (P < 0.05) phosphorylated Akt and ERK1/2 in COT arteries compared to Control cows. By day 250, however, treatment differences in COT vascularity and phosphorylated Akt and ERK1/2 in COT arteries were lost. On both gestational days, no treatment difference was observed in the levels of phosphorylated Akt or ERK1/2 in CAR arteries. CAR vascularity was similar across treatment on day 125, but tended to be greater (P < 0.10) in NR than Control cows on day 250. These data suggest that conceptuses react to an early gestational nutrient restriction by up-regulating COT growth signaling pathways associated with angiogenesis, and that these compensations do not persist to term.

Original languageEnglish (US)
Pages (from-to)361-368
Number of pages8
JournalPlacenta
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

Keywords

  • Akt and ERK1/2 phosphorylation
  • Cow
  • Nutrient restriction
  • Placentome vascularity

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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