Hemoglobin A(1c) (Hgb A(1c)) levels were determined within 24 hours after delivery in 88 nondiabetic and 73 diabetic women belonging to White's classes A to D. Diet-controlled gestational diabetic women had mean (±SD) Hgb A(1c) levels similar to those of nondiabetics (5.8 ± 0.18% vs 5.7 ± 0.08%). Mean Hgb A(1c) levels were higher in insulin-requiring gestational (6.4 ± 0.20%, P < .05) and permanent (6.5 ± 0.27%, P < .05) diabetics than in nondiabetics. The proportions of subjects with levels above the normal range were also larger in the insulin-requiring groups. Mean Hgb A(1c) levels and the proportions of abnormally high levels were similar for mothers of macrosomic and of normally grown neonates in the nondiabetic as well adn in the various diabetes groups. There was no correlation betweeen maternal Hgb A(1c) level and neonatal birth weight, either real or relative. There were also no statistically significant differences in mean Hgb A(1c) levels between mothers of neonates with or without hypoglycemia within four hours of brith. Hgb A(1c) measurement did not permit differentiation between those mothers of macrosomic neonates who were diabetic and those who were not. In conclusion, although Hgb A(1c) level has been shown to reflect diabetic control, our data suggest that it may not be reliable as an indicator of fine tuning during the third trimester of pregnancy or as a pyredictor of the effects of diabetes on the fetus.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Jan 1 1982|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health