Mast cells: Multitalented facilitators of protection against bacterial pathogens

Nikita H. Trivedi; M. Neal Guentzel; Annette R. Rodriguez; Jieh Juen Yu; Thomas G. Forsthuber; Bernard P. Arulanandam

doi:10.1586/eci.12.95

Mast cells: Multitalented facilitators of protection against bacterial pathogens

Nikita H. Trivedi, M. Neal Guentzel, Annette R. Rodriguez, Jieh Juen Yu, Thomas G. Forsthuber, Bernard P. Arulanandam

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.

Original language	English (US)
Pages (from-to)	129-138
Number of pages	10
Journal	Expert Review of Clinical Immunology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1586/eci.12.95
State	Published - Feb 2013

Keywords

infection
mast cells
vaccine adjuvant

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1586/eci.12.95

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title = "Mast cells: Multitalented facilitators of protection against bacterial pathogens",

abstract = "Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.",

keywords = "infection, mast cells, vaccine adjuvant",

author = "Trivedi, {Nikita H.} and Guentzel, {M. Neal} and Rodriguez, {Annette R.} and Yu, {Jieh Juen} and Forsthuber, {Thomas G.} and Arulanandam, {Bernard P.}",

note = "Funding Information: This work was supported by the Army Research Office of the Department of Defense under contract No. W911NF-11-1-0136 and Research Centers in Minority Institutions (RCMI; NIH G12MD007591). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2013",

month = feb,

doi = "10.1586/eci.12.95",

language = "English (US)",

volume = "9",

pages = "129--138",

journal = "Expert Review of Clinical Immunology",

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AU - Trivedi, Nikita H.

AU - Guentzel, M. Neal

AU - Rodriguez, Annette R.

AU - Yu, Jieh Juen

AU - Forsthuber, Thomas G.

AU - Arulanandam, Bernard P.

N1 - Funding Information: This work was supported by the Army Research Office of the Department of Defense under contract No. W911NF-11-1-0136 and Research Centers in Minority Institutions (RCMI; NIH G12MD007591). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2013/2

Y1 - 2013/2

N2 - Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.

AB - Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.

KW - infection

KW - mast cells

KW - vaccine adjuvant

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Mast cells: Multitalented facilitators of protection against bacterial pathogens

Abstract

Keywords

ASJC Scopus subject areas

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