Mast cells: Multitalented facilitators of protection against bacterial pathogens

Nikita H. Trivedi, M. Neal Guentzel, Annette R. Rodriguez, Jieh Juen Yu, Thomas G. Forsthuber, Bernard P. Arulanandam

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
JournalExpert Review of Clinical Immunology
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • infection
  • mast cells
  • vaccine adjuvant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Mast cells: Multitalented facilitators of protection against bacterial pathogens'. Together they form a unique fingerprint.

  • Cite this

    Trivedi, N. H., Guentzel, M. N., Rodriguez, A. R., Yu, J. J., Forsthuber, T. G., & Arulanandam, B. P. (2013). Mast cells: Multitalented facilitators of protection against bacterial pathogens. Expert Review of Clinical Immunology, 9(2), 129-138. https://doi.org/10.1586/eci.12.95