Mast cells: Multitalented facilitators of protection against bacterial pathogens

Nikita H. Trivedi, M. Neal Guentzel, Annette R. Rodriguez, Jieh Juen Yu, Thomas G. Forsthuber, Bernard P. Arulanandam

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
JournalExpert Review of Clinical Immunology
Issue number2
StatePublished - Feb 2013


  • infection
  • mast cells
  • vaccine adjuvant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Mast cells: Multitalented facilitators of protection against bacterial pathogens'. Together they form a unique fingerprint.

Cite this