Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research

Jianing Wang, Chunyan Wang, Xianlin Han

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Shotgun lipidomics is an analytical approach for large-scale and systematic analysis of the composition, structure, and quantity of cellular lipids directly from lipid extracts of biological samples by mass spectrometry. This approach possesses advantages of high throughput and quantitative accuracy, especially in absolute quantification. As cancer research deepens at the level of quantitative biology and metabolomics, the demand for lipidomics approaches such as shotgun lipidomics is becoming greater. In this chapter, the principles, approaches, and some applications of shotgun lipidomics for cancer research are overviewed.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages39-55
Number of pages17
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1280
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cancer lipidomics
  • Direct infusion-based shotgun lipidomics
  • Imaging lipidomics
  • Mass spectrometry
  • Shotgun lipidomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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