Marrow Scanning in Evaluation of Hemopoiesis After Radiotherapy

Richard L. Degowin; Tuhin K. Chaudhuri; James H. Christie; Manuel N. Callis; Allan L. Mueller

doi:10.1001/archinte.1974.00320200107015

Marrow Scanning in Evaluation of Hemopoiesis After Radiotherapy

Richard L. Degowin, Tuhin K. Chaudhuri, James H. Christie, Manuel N. Callis, Allan L. Mueller

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Focal ablation of erythropoiesis in the bone marrows of five patients who had received radiotherapy for malignant lymphoma was demonstrated by erythropoietic marrow scanning with radioactive iron (⁵⁹ Fe). Concomitant clinical, morphologic, and ferrokinetic studies confirmed the findings obtained from whole-body linear profiles and erythropoietic marrow scans. These techniques permitted distinction between focal and generalized hemopoietic insufficiency and should prove useful in evaluating the distribution and function of erythropoietic tissue. Results of these preliminary studies suggest that doses of irradiation commonly employed in the initial treatment of malignant lymphoma may prevent repopulation of bone marrow in radiated areas for at least one to three years. Compensatory hyperplasia of hemopoietic tissue occurred in the ribs and axial skeleton of several adult patients.

Original language	English (US)
Pages (from-to)	297-303
Number of pages	7
Journal	Archives of Internal Medicine
Volume	134
Issue number	2
DOIs	https://doi.org/10.1001/archinte.1974.00320200107015
State	Published - Aug 1974
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1001/archinte.1974.00320200107015

Cite this

@article{d0ecdd7f8bbb45cf8986857afe3572d7,

title = "Marrow Scanning in Evaluation of Hemopoiesis After Radiotherapy",

abstract = "Focal ablation of erythropoiesis in the bone marrows of five patients who had received radiotherapy for malignant lymphoma was demonstrated by erythropoietic marrow scanning with radioactive iron (59 Fe). Concomitant clinical, morphologic, and ferrokinetic studies confirmed the findings obtained from whole-body linear profiles and erythropoietic marrow scans. These techniques permitted distinction between focal and generalized hemopoietic insufficiency and should prove useful in evaluating the distribution and function of erythropoietic tissue. Results of these preliminary studies suggest that doses of irradiation commonly employed in the initial treatment of malignant lymphoma may prevent repopulation of bone marrow in radiated areas for at least one to three years. Compensatory hyperplasia of hemopoietic tissue occurred in the ribs and axial skeleton of several adult patients.",

author = "Degowin, {Richard L.} and Chaudhuri, {Tuhin K.} and Christie, {James H.} and Callis, {Manuel N.} and Mueller, {Allan L.}",

year = "1974",

month = aug,

doi = "10.1001/archinte.1974.00320200107015",

language = "English (US)",

volume = "134",

pages = "297--303",

journal = "Archives of Internal Medicine",

issn = "0003-9926",

publisher = "American Medical Association",

number = "2",

}

TY - JOUR

T1 - Marrow Scanning in Evaluation of Hemopoiesis After Radiotherapy

AU - Degowin, Richard L.

AU - Chaudhuri, Tuhin K.

AU - Christie, James H.

AU - Callis, Manuel N.

AU - Mueller, Allan L.

PY - 1974/8

Y1 - 1974/8

N2 - Focal ablation of erythropoiesis in the bone marrows of five patients who had received radiotherapy for malignant lymphoma was demonstrated by erythropoietic marrow scanning with radioactive iron (59 Fe). Concomitant clinical, morphologic, and ferrokinetic studies confirmed the findings obtained from whole-body linear profiles and erythropoietic marrow scans. These techniques permitted distinction between focal and generalized hemopoietic insufficiency and should prove useful in evaluating the distribution and function of erythropoietic tissue. Results of these preliminary studies suggest that doses of irradiation commonly employed in the initial treatment of malignant lymphoma may prevent repopulation of bone marrow in radiated areas for at least one to three years. Compensatory hyperplasia of hemopoietic tissue occurred in the ribs and axial skeleton of several adult patients.

AB - Focal ablation of erythropoiesis in the bone marrows of five patients who had received radiotherapy for malignant lymphoma was demonstrated by erythropoietic marrow scanning with radioactive iron (59 Fe). Concomitant clinical, morphologic, and ferrokinetic studies confirmed the findings obtained from whole-body linear profiles and erythropoietic marrow scans. These techniques permitted distinction between focal and generalized hemopoietic insufficiency and should prove useful in evaluating the distribution and function of erythropoietic tissue. Results of these preliminary studies suggest that doses of irradiation commonly employed in the initial treatment of malignant lymphoma may prevent repopulation of bone marrow in radiated areas for at least one to three years. Compensatory hyperplasia of hemopoietic tissue occurred in the ribs and axial skeleton of several adult patients.

UR - http://www.scopus.com/inward/record.url?scp=84942949464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942949464&partnerID=8YFLogxK

U2 - 10.1001/archinte.1974.00320200107015

DO - 10.1001/archinte.1974.00320200107015

M3 - Article

C2 - 4407883

AN - SCOPUS:84942949464

SN - 0003-9926

VL - 134

SP - 297

EP - 303

JO - Archives of Internal Medicine

JF - Archives of Internal Medicine

IS - 2

ER -

Marrow Scanning in Evaluation of Hemopoiesis After Radiotherapy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this