Marked proteinuria in hypertensive nephrosclerosis

S. K. Mujais, D. S. Emmanouel, B. S. Kasinath, B. H. Spargo

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Heavy proteinuria in patients with essential hypertension raises the question of underlying primary renal disease. While malignant hypertension may be associated with proteinuria in the nephrotic range, it is generally held that protein excretion in benign nephrosclerosis is almost invariably less than 0.5-1.0 g/24 h. We report 18 patients with biopsy-proven hypertensive nephropathy and heavy proteinuria, of which only 6 had malignant hypertension. In the remaining 12 patients with benign nephrosclerosis, protein excretion reached up to 6.5 g/24 h, and nephrotic range proteinuria was present in 3 patients. All patients with heavy proteinuria suffered from long-standing moderate or severe, poorly controlled hypertension and were azotemic. We suggest that hypertensive nephrosclerosis be included in the differential diagnosis of massive proteinuria accompanying azotemia in poorly controlled hypertensives.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalAmerican journal of nephrology
Issue number3
StatePublished - 1985

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Marked proteinuria in hypertensive nephrosclerosis'. Together they form a unique fingerprint.

Cite this