Marital status, alcohol dependence, and GABRA2

Evidence for gene-environment correlation and interaction

Danielle M. Dick, Arpana Agrawal, Marc A. Schuckit, Laura Bierut, Anthony Hinrichs, Louis Fox, Joseph Mullaney, C. Robert Cloninger, Victor Hesselbrock, John I. Nurnberger, Laura Almasy, Tatiana Foroud, Bernice Porjesz, Howard Edenberg, Henri Begleiter

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Objective: The gene GABRA2 has been associated with the risk for alcohol dependence in independent samples. This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence. Method: Data from more than 1,900 male and female subjects from the Collaborative Study of the Genetics of Alcoholism (COGA) sample were analyzed. Subjects were recruited based on membership in a family with multiple individuals with alcoholism. A series of analyses was performed to evaluate the relationship between the following: (1) GABRA2 and alcohol dependence, (2) marital status and alcohol dependence, (3) GABRA2 and marital status, and (4) interactions between GABRA2 and marital status on the development of alcohol dependence in the high-risk COGA sample. Additional analyses were carried out in a sample of ∼900 individuals from control families to test the generalizability of results. Results: Both GABRA2 and marital status contributed independently to the development of alcohol dependence in the COGA sample. The high-risk genotype at GABRA2 was also related to a decreased likelihood of marrying and an increased likelihood of divorce, which appeared to be mediated in part by personality characteristics. There was also differential risk associated with the GABRA2 genotype according to marital status. Conclusions: These analyses provide evidence of both gene-environment correlation and gene-environment interaction associated with GABRA2, marital status, and alcohol dependence. They illustrate the complex pathways by which genotype and environmental risk factors act and interact to influence alcohol dependence and challenge traditional conceptualizations of " environmental" risk factors.

Original languageEnglish (US)
Pages (from-to)185-194
Number of pages10
JournalJournal of Studies on Alcohol
Volume67
Issue number2
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Gene-Environment Interaction
Marital Status
marital status
Alcoholism
Genes
alcohol
Alcohols
interaction
alcoholism
evidence
Genotype
divorce
personality
Divorce
Personality

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychology(all)

Cite this

Dick, D. M., Agrawal, A., Schuckit, M. A., Bierut, L., Hinrichs, A., Fox, L., ... Begleiter, H. (2006). Marital status, alcohol dependence, and GABRA2: Evidence for gene-environment correlation and interaction. Journal of Studies on Alcohol, 67(2), 185-194.

Marital status, alcohol dependence, and GABRA2 : Evidence for gene-environment correlation and interaction. / Dick, Danielle M.; Agrawal, Arpana; Schuckit, Marc A.; Bierut, Laura; Hinrichs, Anthony; Fox, Louis; Mullaney, Joseph; Cloninger, C. Robert; Hesselbrock, Victor; Nurnberger, John I.; Almasy, Laura; Foroud, Tatiana; Porjesz, Bernice; Edenberg, Howard; Begleiter, Henri.

In: Journal of Studies on Alcohol, Vol. 67, No. 2, 03.2006, p. 185-194.

Research output: Contribution to journalArticle

Dick, DM, Agrawal, A, Schuckit, MA, Bierut, L, Hinrichs, A, Fox, L, Mullaney, J, Cloninger, CR, Hesselbrock, V, Nurnberger, JI, Almasy, L, Foroud, T, Porjesz, B, Edenberg, H & Begleiter, H 2006, 'Marital status, alcohol dependence, and GABRA2: Evidence for gene-environment correlation and interaction', Journal of Studies on Alcohol, vol. 67, no. 2, pp. 185-194.
Dick DM, Agrawal A, Schuckit MA, Bierut L, Hinrichs A, Fox L et al. Marital status, alcohol dependence, and GABRA2: Evidence for gene-environment correlation and interaction. Journal of Studies on Alcohol. 2006 Mar;67(2):185-194.
Dick, Danielle M. ; Agrawal, Arpana ; Schuckit, Marc A. ; Bierut, Laura ; Hinrichs, Anthony ; Fox, Louis ; Mullaney, Joseph ; Cloninger, C. Robert ; Hesselbrock, Victor ; Nurnberger, John I. ; Almasy, Laura ; Foroud, Tatiana ; Porjesz, Bernice ; Edenberg, Howard ; Begleiter, Henri. / Marital status, alcohol dependence, and GABRA2 : Evidence for gene-environment correlation and interaction. In: Journal of Studies on Alcohol. 2006 ; Vol. 67, No. 2. pp. 185-194.
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AU - Bierut, Laura

AU - Hinrichs, Anthony

AU - Fox, Louis

AU - Mullaney, Joseph

AU - Cloninger, C. Robert

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AU - Edenberg, Howard

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