Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone

P. A. Lalley; A. Y. Sakaguchi; R. L. Eddy; N. H. Honey; G. I. Bell; L. P. Shen; W. J. Rutter; J. W. Jacobs; G. Heinrich; W. W. Chin; S. L. Naylor

doi:10.1159/000132350

Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone

P. A. Lalley, A. Y. Sakaguchi, R. L. Eddy, N. H. Honey, G. I. Bell, L. P. Shen, W. J. Rutter, J. W. Jacobs, G. Heinrich, W. W. Chin, S. L. Naylor

Cell Systems & Anatomy

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Abstract

Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.

Original language	English (US)
Pages (from-to)	92-97
Number of pages	6
Journal	Cytogenetic and Genome Research
Volume	44
Issue number	2-3
DOIs	https://doi.org/10.1159/000132350
State	Published - 1987

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1159/000132350

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Mapping polypeptide hormone genes in the mouse : Somatostatin, glucagon, calcitonin, and parathyroid hormone. / Lalley, P. A.; Sakaguchi, A. Y.; Eddy, R. L.; Honey, N. H.; Bell, G. I.; Shen, L. P.; Rutter, W. J.; Jacobs, J. W.; Heinrich, G.; Chin, W. W.; Naylor, S. L.

In: Cytogenetic and Genome Research, Vol. 44, No. 2-3, 1987, p. 92-97.

Research output: Contribution to journal › Article › peer-review

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title = "Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone",

abstract = "Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.",

author = "Lalley, {P. A.} and Sakaguchi, {A. Y.} and Eddy, {R. L.} and Honey, {N. H.} and Bell, {G. I.} and Shen, {L. P.} and Rutter, {W. J.} and Jacobs, {J. W.} and G. Heinrich and Chin, {W. W.} and Naylor, {S. L.}",

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doi = "10.1159/000132350",

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AU - Lalley, P. A.

AU - Sakaguchi, A. Y.

AU - Eddy, R. L.

AU - Honey, N. H.

AU - Bell, G. I.

AU - Shen, L. P.

AU - Rutter, W. J.

AU - Jacobs, J. W.

AU - Heinrich, G.

AU - Chin, W. W.

AU - Naylor, S. L.

PY - 1987

Y1 - 1987

N2 - Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.

AB - Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.

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Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone

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