Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone

P. A. Lalley, A. Y. Sakaguchi, R. L. Eddy, N. H. Honey, G. I. Bell, L. P. Shen, W. J. Rutter, J. W. Jacobs, G. Heinrich, W. W. Chin, S. L. Naylor

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalCytogenetic and Genome Research
Volume44
Issue number2-3
DOIs
StatePublished - Jan 1 1987

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Lalley, P. A., Sakaguchi, A. Y., Eddy, R. L., Honey, N. H., Bell, G. I., Shen, L. P., Rutter, W. J., Jacobs, J. W., Heinrich, G., Chin, W. W., & Naylor, S. L. (1987). Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone. Cytogenetic and Genome Research, 44(2-3), 92-97. https://doi.org/10.1159/000132350