Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization

Christiane Löffler; V. V.N.Gopal Rao; Ingo Hansmann

doi:10.1007/BF00204188

Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization

Christiane Löffler, V. V.N.Gopal Rao, Ingo Hansmann

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Ribophorin I and II (RPN I and RPN II), two specific glycoproteins, span the rough regions of the endoplasmic reticulum (RER) and are thought to play an important role either in translocation or in the maintenance of RER. Studies with human-mouse somatic cell hybrids have localized the gene for RPN I on human chromosome 3q, while RPN II is on chromosome 20. Using a radioactive labelled cDNA probe, we have regionally mapped the RPN II gene to human chromosome 20q12-q13.1 by in situ hybridization. This assignment predicts a location of the murine homologue, Rpn-2, to the syntenic segment on mouse chromosome 2 in close proximity to Ada, Src and Gnas.

Original language	English (US)
Pages (from-to)	221-222
Number of pages	2
Journal	Human Genetics
Volume	87
Issue number	2
DOIs	https://doi.org/10.1007/BF00204188
State	Published - Jun 1991
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Access to Document

10.1007/BF00204188

Cite this

@article{06db15e35ae648f3ab209c5016357cbd,

title = "Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization",

abstract = "Ribophorin I and II (RPN I and RPN II), two specific glycoproteins, span the rough regions of the endoplasmic reticulum (RER) and are thought to play an important role either in translocation or in the maintenance of RER. Studies with human-mouse somatic cell hybrids have localized the gene for RPN I on human chromosome 3q, while RPN II is on chromosome 20. Using a radioactive labelled cDNA probe, we have regionally mapped the RPN II gene to human chromosome 20q12-q13.1 by in situ hybridization. This assignment predicts a location of the murine homologue, Rpn-2, to the syntenic segment on mouse chromosome 2 in close proximity to Ada, Src and Gnas.",

author = "Christiane L{\"o}ffler and Rao, {V. V.N.Gopal} and Ingo Hansmann",

year = "1991",

month = jun,

doi = "10.1007/BF00204188",

language = "English (US)",

volume = "87",

pages = "221--222",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization

AU - Löffler, Christiane

AU - Rao, V. V.N.Gopal

AU - Hansmann, Ingo

PY - 1991/6

Y1 - 1991/6

N2 - Ribophorin I and II (RPN I and RPN II), two specific glycoproteins, span the rough regions of the endoplasmic reticulum (RER) and are thought to play an important role either in translocation or in the maintenance of RER. Studies with human-mouse somatic cell hybrids have localized the gene for RPN I on human chromosome 3q, while RPN II is on chromosome 20. Using a radioactive labelled cDNA probe, we have regionally mapped the RPN II gene to human chromosome 20q12-q13.1 by in situ hybridization. This assignment predicts a location of the murine homologue, Rpn-2, to the syntenic segment on mouse chromosome 2 in close proximity to Ada, Src and Gnas.

AB - Ribophorin I and II (RPN I and RPN II), two specific glycoproteins, span the rough regions of the endoplasmic reticulum (RER) and are thought to play an important role either in translocation or in the maintenance of RER. Studies with human-mouse somatic cell hybrids have localized the gene for RPN I on human chromosome 3q, while RPN II is on chromosome 20. Using a radioactive labelled cDNA probe, we have regionally mapped the RPN II gene to human chromosome 20q12-q13.1 by in situ hybridization. This assignment predicts a location of the murine homologue, Rpn-2, to the syntenic segment on mouse chromosome 2 in close proximity to Ada, Src and Gnas.

UR - http://www.scopus.com/inward/record.url?scp=0025780869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025780869&partnerID=8YFLogxK

U2 - 10.1007/BF00204188

DO - 10.1007/BF00204188

M3 - Article

C2 - 2066112

AN - SCOPUS:0025780869

SN - 0340-6717

VL - 87

SP - 221

EP - 222

JO - Human Genetics

JF - Human Genetics

IS - 2

ER -

Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this