Mapping of the DNA locus D4S10 and the linked Huntington’s disease gene to 4p16→p15

B. U. Zabel; Susan L. Naylor; A. Y. Sakaguchi; J. F. Gusella

doi:10.1159/000132276

Mapping of the DNA locus D4S10 and the linked Huntington’s disease gene to 4p16→p15

B. U. Zabel, Susan L. Naylor, A. Y. Sakaguchi, J. F. Gusella

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in Hindill-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntington’s disease gene. With in situ hybridization, we mapped D4SI0 to the terminal region of the short arm of chromosome 4. localizing the Huntington’s disease gene to bands 4p 16→p 15. This information may prove useful for the development of strategics to clone the Huntington’s disease gene.

Original language	English (US)
Pages (from-to)	187-190
Number of pages	4
Journal	Cytogenetics and Cell Genetics
Volume	42
Issue number	4
DOIs	https://doi.org/10.1159/000132276
State	Published - 1986

ASJC Scopus subject areas

Genetics
Cell Biology

Access to Document

10.1159/000132276

Cite this

@article{4ef6f878cf4241e4b709cf309cb13e55,

title = "Mapping of the DNA locus D4S10 and the linked Huntington{\textquoteright}s disease gene to 4p16→p15",

abstract = "An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in Hindill-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntington{\textquoteright}s disease gene. With in situ hybridization, we mapped D4SI0 to the terminal region of the short arm of chromosome 4. localizing the Huntington{\textquoteright}s disease gene to bands 4p 16→p 15. This information may prove useful for the development of strategics to clone the Huntington{\textquoteright}s disease gene.",

author = "Zabel, {B. U.} and Naylor, {Susan L.} and Sakaguchi, {A. Y.} and Gusella, {J. F.}",

year = "1986",

doi = "10.1159/000132276",

language = "English (US)",

volume = "42",

pages = "187--190",

journal = "Cytogenetics and Cell Genetics",

issn = "0301-0171",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - Mapping of the DNA locus D4S10 and the linked Huntington’s disease gene to 4p16→p15

AU - Zabel, B. U.

AU - Naylor, Susan L.

AU - Sakaguchi, A. Y.

AU - Gusella, J. F.

PY - 1986

Y1 - 1986

N2 - An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in Hindill-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntington’s disease gene. With in situ hybridization, we mapped D4SI0 to the terminal region of the short arm of chromosome 4. localizing the Huntington’s disease gene to bands 4p 16→p 15. This information may prove useful for the development of strategics to clone the Huntington’s disease gene.

AB - An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in Hindill-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntington’s disease gene. With in situ hybridization, we mapped D4SI0 to the terminal region of the short arm of chromosome 4. localizing the Huntington’s disease gene to bands 4p 16→p 15. This information may prove useful for the development of strategics to clone the Huntington’s disease gene.

UR - http://www.scopus.com/inward/record.url?scp=0022471234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022471234&partnerID=8YFLogxK

U2 - 10.1159/000132276

DO - 10.1159/000132276

M3 - Article

C2 - 2944714

AN - SCOPUS:0022471234

SN - 0301-0171

VL - 42

SP - 187

EP - 190

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 4

ER -

Mapping of the DNA locus D4S10 and the linked Huntington’s disease gene to 4p16→p15

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this