Mapping of the DNA locus D4S10 and the linked Huntington’s disease gene to 4p16→p15

B. U. Zabel, Susan L. Naylor, A. Y. Sakaguchi, J. F. Gusella

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in Hindill-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntington’s disease gene. With in situ hybridization, we mapped D4SI0 to the terminal region of the short arm of chromosome 4. localizing the Huntington’s disease gene to bands 4p 16→p 15. This information may prove useful for the development of strategics to clone the Huntington’s disease gene.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalCytogenetic and Genome Research
Volume42
Issue number4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Mapping of the DNA locus D4S10 and the linked Huntington’s disease gene to 4p16→p15'. Together they form a unique fingerprint.

  • Cite this