An anonymous DNA fragment (G8) detects two restriction fragment length polymorphic alleles (RFLPs) called D4S10 in Hindill-digested human genomic DNA. This segment had been assigned to chromosome 4 and shows close linkage to the Huntington’s disease gene. With in situ hybridization, we mapped D4SI0 to the terminal region of the short arm of chromosome 4. localizing the Huntington’s disease gene to bands 4p 16→p 15. This information may prove useful for the development of strategics to clone the Huntington’s disease gene.
ASJC Scopus subject areas
- Molecular Biology