Mapping miRNA regulation to functional gene sets

Yidong Chen, Hung I.Harry Chen, Yufei Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Distinct cellular functions and biological process of cells will likely be reflected in alteration in levels of genes as well as their regulatory components, such as the level of miRNAs. By employing systems biology approaches, we will be able to unambiguously identify the regulatory pathways and biological processes that are unique to specific disease states or responses to treatment. In this study, we propose an additive and weighted model to combine all possible miRNA target predictions to study the regulation change at a specific gene set, pathway or interaction network, rather than individual miRNA, enabling researchers to construct regulation hypothesis at pathway or interaction network level.

Original languageEnglish (US)
Title of host publicationProceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009
Pages122-125
Number of pages4
DOIs
StatePublished - Nov 26 2009
Event2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009 - Shanghai, China
Duration: Aug 3 2009Aug 5 2009

Publication series

NameProceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009

Conference

Conference2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009
CountryChina
CityShanghai
Period8/3/098/5/09

Keywords

  • Gene regulation
  • MiRNA
  • Pathway analysis

ASJC Scopus subject areas

  • Software
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Mapping miRNA regulation to functional gene sets'. Together they form a unique fingerprint.

  • Cite this

    Chen, Y., Chen, H. I. H., & Huang, Y. (2009). Mapping miRNA regulation to functional gene sets. In Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009 (pp. 122-125). [5260723] (Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009). https://doi.org/10.1109/IJCBS.2009.64