Mapping human visual cortex with positron emission tomography

Peter T Fox, Mark A. Mintun, Marcus E. Raichle, Francis M. Miezin, John M. Allman, David C. Van Essen

Research output: Contribution to journalArticle

286 Citations (Scopus)

Abstract

Positron-emission tomography (PET) can localize functions of the human brain by imaging regional cerebral blood flow (CBF) during voluntary behaviour. Functional brain mapping with PET, however, has been hindered by PET's poor spatial resolution (typically >1 cm). We have developed an image-analysis strategy that can map functional zones not resolved by conventional PET images. Brain areas selectively activated by a behavioural task can be isolated by subtracting a paired control-state image from the task-state image, thereby removing areas not recruited by the task. When imaged in isolation the centre of an activated area can be located very precisely. This allows subtle shifts in response locale due to changes in task to be detected readily despite poor spatial resolution. As an initial application of this strategy we mapped the retinal projection topography of human primary visual cortex. Functional zones separated by less than 3 mm (centre-to-centre) were differentiated using PET CBF images with a spatial resolution of 18 mm. This technique is not limited to a particular brain area or type of behaviour but does require that the increase in CBF produced by the task be both intense and focal.

Original languageEnglish (US)
Pages (from-to)806-809
Number of pages4
JournalNature
Volume323
Issue number6091
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Visual Cortex
Positron-Emission Tomography
Brain Mapping
Regional Blood Flow
Brain
Neuroimaging

ASJC Scopus subject areas

  • General

Cite this

Fox, P. T., Mintun, M. A., Raichle, M. E., Miezin, F. M., Allman, J. M., & Van Essen, D. C. (1986). Mapping human visual cortex with positron emission tomography. Nature, 323(6091), 806-809. https://doi.org/10.1038/323806a0

Mapping human visual cortex with positron emission tomography. / Fox, Peter T; Mintun, Mark A.; Raichle, Marcus E.; Miezin, Francis M.; Allman, John M.; Van Essen, David C.

In: Nature, Vol. 323, No. 6091, 1986, p. 806-809.

Research output: Contribution to journalArticle

Fox, PT, Mintun, MA, Raichle, ME, Miezin, FM, Allman, JM & Van Essen, DC 1986, 'Mapping human visual cortex with positron emission tomography', Nature, vol. 323, no. 6091, pp. 806-809. https://doi.org/10.1038/323806a0
Fox PT, Mintun MA, Raichle ME, Miezin FM, Allman JM, Van Essen DC. Mapping human visual cortex with positron emission tomography. Nature. 1986;323(6091):806-809. https://doi.org/10.1038/323806a0
Fox, Peter T ; Mintun, Mark A. ; Raichle, Marcus E. ; Miezin, Francis M. ; Allman, John M. ; Van Essen, David C. / Mapping human visual cortex with positron emission tomography. In: Nature. 1986 ; Vol. 323, No. 6091. pp. 806-809.
@article{9ecf57c5886b4968af9e3662e6498a62,
title = "Mapping human visual cortex with positron emission tomography",
abstract = "Positron-emission tomography (PET) can localize functions of the human brain by imaging regional cerebral blood flow (CBF) during voluntary behaviour. Functional brain mapping with PET, however, has been hindered by PET's poor spatial resolution (typically >1 cm). We have developed an image-analysis strategy that can map functional zones not resolved by conventional PET images. Brain areas selectively activated by a behavioural task can be isolated by subtracting a paired control-state image from the task-state image, thereby removing areas not recruited by the task. When imaged in isolation the centre of an activated area can be located very precisely. This allows subtle shifts in response locale due to changes in task to be detected readily despite poor spatial resolution. As an initial application of this strategy we mapped the retinal projection topography of human primary visual cortex. Functional zones separated by less than 3 mm (centre-to-centre) were differentiated using PET CBF images with a spatial resolution of 18 mm. This technique is not limited to a particular brain area or type of behaviour but does require that the increase in CBF produced by the task be both intense and focal.",
author = "Fox, {Peter T} and Mintun, {Mark A.} and Raichle, {Marcus E.} and Miezin, {Francis M.} and Allman, {John M.} and {Van Essen}, {David C.}",
year = "1986",
doi = "10.1038/323806a0",
language = "English (US)",
volume = "323",
pages = "806--809",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6091",

}

TY - JOUR

T1 - Mapping human visual cortex with positron emission tomography

AU - Fox, Peter T

AU - Mintun, Mark A.

AU - Raichle, Marcus E.

AU - Miezin, Francis M.

AU - Allman, John M.

AU - Van Essen, David C.

PY - 1986

Y1 - 1986

N2 - Positron-emission tomography (PET) can localize functions of the human brain by imaging regional cerebral blood flow (CBF) during voluntary behaviour. Functional brain mapping with PET, however, has been hindered by PET's poor spatial resolution (typically >1 cm). We have developed an image-analysis strategy that can map functional zones not resolved by conventional PET images. Brain areas selectively activated by a behavioural task can be isolated by subtracting a paired control-state image from the task-state image, thereby removing areas not recruited by the task. When imaged in isolation the centre of an activated area can be located very precisely. This allows subtle shifts in response locale due to changes in task to be detected readily despite poor spatial resolution. As an initial application of this strategy we mapped the retinal projection topography of human primary visual cortex. Functional zones separated by less than 3 mm (centre-to-centre) were differentiated using PET CBF images with a spatial resolution of 18 mm. This technique is not limited to a particular brain area or type of behaviour but does require that the increase in CBF produced by the task be both intense and focal.

AB - Positron-emission tomography (PET) can localize functions of the human brain by imaging regional cerebral blood flow (CBF) during voluntary behaviour. Functional brain mapping with PET, however, has been hindered by PET's poor spatial resolution (typically >1 cm). We have developed an image-analysis strategy that can map functional zones not resolved by conventional PET images. Brain areas selectively activated by a behavioural task can be isolated by subtracting a paired control-state image from the task-state image, thereby removing areas not recruited by the task. When imaged in isolation the centre of an activated area can be located very precisely. This allows subtle shifts in response locale due to changes in task to be detected readily despite poor spatial resolution. As an initial application of this strategy we mapped the retinal projection topography of human primary visual cortex. Functional zones separated by less than 3 mm (centre-to-centre) were differentiated using PET CBF images with a spatial resolution of 18 mm. This technique is not limited to a particular brain area or type of behaviour but does require that the increase in CBF produced by the task be both intense and focal.

UR - http://www.scopus.com/inward/record.url?scp=0022979499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022979499&partnerID=8YFLogxK

U2 - 10.1038/323806a0

DO - 10.1038/323806a0

M3 - Article

C2 - 3534580

AN - SCOPUS:0022979499

VL - 323

SP - 806

EP - 809

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6091

ER -