Mapping ecologically relevant social behaviours by gene knockout in wild mice

Lea Chalfin, Molly Dayan, Dana Rubi Levy, Steven N. Austad, Richard A. Miller, Fuad A. Iraqi, Catherine Dulac, Tali Kimchi

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, and adaptation to captivity, is of limited use for the study of fitness-driven behavioural responses that characterize the ancestral wild house mouse. Here, we demonstrate that the backcrossing of wild mice with knockout mutant laboratory mice retrieves behavioural traits exhibited exclusively by the wild house mouse, thereby unmasking gene functions inaccessible in the domesticated mutant model. Furthermore, we show that domestication had a much greater impact on females than on males, erasing many behavioural traits of the ancestral wild female. Hence, compared with laboratory mice, wild-derived mutant mice constitute an improved model system to gain insights into neuronal mechanisms underlying normal and pathological sexually dimorphic social behaviours.

Original languageEnglish (US)
Article number4569
JournalNature Communications
Volume5
DOIs
StatePublished - Aug 5 2014
Externally publishedYes

Fingerprint

Gene Knockout Techniques
Social Behavior
genes
mice
Genes
Inbreeding
Brain
Gene Targeting
fitness
Knockout Mice
brain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Chalfin, L., Dayan, M., Levy, D. R., Austad, S. N., Miller, R. A., Iraqi, F. A., ... Kimchi, T. (2014). Mapping ecologically relevant social behaviours by gene knockout in wild mice. Nature Communications, 5, [4569]. https://doi.org/10.1038/ncomms5569

Mapping ecologically relevant social behaviours by gene knockout in wild mice. / Chalfin, Lea; Dayan, Molly; Levy, Dana Rubi; Austad, Steven N.; Miller, Richard A.; Iraqi, Fuad A.; Dulac, Catherine; Kimchi, Tali.

In: Nature Communications, Vol. 5, 4569, 05.08.2014.

Research output: Contribution to journalArticle

Chalfin, L, Dayan, M, Levy, DR, Austad, SN, Miller, RA, Iraqi, FA, Dulac, C & Kimchi, T 2014, 'Mapping ecologically relevant social behaviours by gene knockout in wild mice', Nature Communications, vol. 5, 4569. https://doi.org/10.1038/ncomms5569
Chalfin L, Dayan M, Levy DR, Austad SN, Miller RA, Iraqi FA et al. Mapping ecologically relevant social behaviours by gene knockout in wild mice. Nature Communications. 2014 Aug 5;5. 4569. https://doi.org/10.1038/ncomms5569
Chalfin, Lea ; Dayan, Molly ; Levy, Dana Rubi ; Austad, Steven N. ; Miller, Richard A. ; Iraqi, Fuad A. ; Dulac, Catherine ; Kimchi, Tali. / Mapping ecologically relevant social behaviours by gene knockout in wild mice. In: Nature Communications. 2014 ; Vol. 5.
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