Mapping cortical columnar structures using fMRI

Seong Gi Kim, Timothy Q. Duong

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Mapping cortical columnar structures is important to understand cortical information processing. To map submillimeter columnar structures noninvasively, we have evaluated various functional magnetic resonance imaging (fMRI) techniques using a well-established feline orientation column model. The conventional positive blood oxygenation level-dependent (BOLD) signal is widespread and diffuse due to large venous vessel contributions, resulting in its poor specificity to columns. However, the early-negative BOLD signal is induced by the early oxygen consumption increase without significant change in blood flow. This negative signal has been successfully applied for columnar mapping. Tissue-specific cerebral blood flow (CBF) response is also specific to individual cortical columns, suggesting that parenchyma-specific fMRI techniques are capable to map individual single-condition functional cortical columns in animals as well as humans.

Original languageEnglish (US)
Pages (from-to)641-644
Number of pages4
JournalPhysiology and Behavior
Volume77
Issue number4-5
DOIs
StatePublished - Dec 2002

Keywords

  • Brain mapping
  • Cerebral blood flow
  • Columns
  • Dip
  • Functional MRI
  • Maps
  • Perfusion

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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