Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa

Jacobus E. Van Der Kaaden, Thomas K. Hemscheidt, Susan L. Mooberry

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalJournal of Natural Products
Volume64
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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