Abstract
A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-105 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa. / Van Der Kaaden, Jacobus E.; Hemscheidt, Thomas K.; Mooberry, Susan L.
In: Journal of Natural Products, Vol. 64, No. 1, 2001, p. 103-105.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa
AU - Van Der Kaaden, Jacobus E.
AU - Hemscheidt, Thomas K.
AU - Mooberry, Susan L
PY - 2001
Y1 - 2001
N2 - A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.
AB - A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.
UR - http://www.scopus.com/inward/record.url?scp=0035143620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035143620&partnerID=8YFLogxK
U2 - 10.1021/np000265r
DO - 10.1021/np000265r
M3 - Article
C2 - 11170679
AN - SCOPUS:0035143620
VL - 64
SP - 103
EP - 105
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 1
ER -