Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa

Jacobus E. Van Der Kaaden, Thomas K. Hemscheidt, Susan L Mooberry

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalJournal of Natural Products
Volume64
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Macaranga
Euphorbiaceae
Stilbenes
stilbenes
drugs
ovarian neoplasms
Bioassay
P-Glycoprotein
Fractionation
application methods
Biological Assay
Pharmaceutical Preparations
Ovarian Neoplasms
Inhibitory Concentration 50
inhibitory concentration 50
fractionation
bioassays
Cells
cell lines
Cell Line

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa. / Van Der Kaaden, Jacobus E.; Hemscheidt, Thomas K.; Mooberry, Susan L.

In: Journal of Natural Products, Vol. 64, No. 1, 2001, p. 103-105.

Research output: Contribution to journalArticle

Van Der Kaaden, Jacobus E. ; Hemscheidt, Thomas K. ; Mooberry, Susan L. / Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa. In: Journal of Natural Products. 2001 ; Vol. 64, No. 1. pp. 103-105.
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