Abstract
A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.
Original language | English (US) |
---|---|
Pages (from-to) | 103-105 |
Number of pages | 3 |
Journal | Journal of Natural Products |
Volume | 64 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry