Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa

Jacobus E. Van Der Kaaden; Thomas K. Hemscheidt; Susan L. Mooberry

doi:10.1021/np000265r

Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa

Jacobus E. Van Der Kaaden, Thomas K. Hemscheidt, Susan L. Mooberry

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC₅₀ value of 1.3 μM in both cases.

Original language	English (US)
Pages (from-to)	103-105
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	1
DOIs	https://doi.org/10.1021/np000265r
State	Published - 2001

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np000265r

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abstract = "A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.",

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AB - A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 μM in both cases.

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Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa

Abstract

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