Abstract
Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P<0.05) between 30 and 120 min and there was a significant inhibition (P<0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r=0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P<0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1079-1083 |
| Number of pages | 5 |
| Journal | The American Journal of Digestive Diseases |
| Volume | 23 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1978 |
| Externally published | Yes |
ASJC Scopus subject areas
- Gastroenterology