Mannitol and glucose - Effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP)

Thomas M. O'Dorisio; James T. Spaeth; Edward W. Martin; Kenneth R. Sirinek; Neil R. Thomford; Ernest L. Mazzaferri; Samuel Cataland

doi:10.1007/BF01072882

Mannitol and glucose - Effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP)

Thomas M. O'Dorisio, James T. Spaeth, Edward W. Martin, Kenneth R. Sirinek, Neil R. Thomford, Ernest L. Mazzaferri, Samuel Cataland

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P<0.05) between 30 and 120 min and there was a significant inhibition (P<0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r=0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P<0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.

Original language	English (US)
Pages (from-to)	1079-1083
Number of pages	5
Journal	The American Journal of Digestive Diseases
Volume	23
Issue number	12
DOIs	https://doi.org/10.1007/BF01072882
State	Published - Dec 1978
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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10.1007/BF01072882

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title = "Mannitol and glucose - Effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP)",

abstract = "Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P<0.05) between 30 and 120 min and there was a significant inhibition (P<0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r=0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P<0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.",

author = "O'Dorisio, {Thomas M.} and Spaeth, {James T.} and Martin, {Edward W.} and Sirinek, {Kenneth R.} and Thomford, {Neil R.} and Mazzaferri, {Ernest L.} and Samuel Cataland",

year = "1978",

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doi = "10.1007/BF01072882",

language = "English (US)",

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AU - O'Dorisio, Thomas M.

AU - Spaeth, James T.

AU - Martin, Edward W.

AU - Sirinek, Kenneth R.

AU - Thomford, Neil R.

AU - Mazzaferri, Ernest L.

AU - Cataland, Samuel

PY - 1978/12

Y1 - 1978/12

N2 - Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P<0.05) between 30 and 120 min and there was a significant inhibition (P<0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r=0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P<0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.

AB - Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P<0.05) between 30 and 120 min and there was a significant inhibition (P<0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r=0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P<0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.

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JF - The American Journal of Digestive Diseases

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ER -

Mannitol and glucose - Effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP)

Abstract

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