Abstract
Noradrenergic and GABA systems may be involved in mania, but there is little information about relationships between the function of these systems and response to specific antimanic treatments. We investigated relationships between indices of catecholamine or GABA system function, pretreatment mania severity and antimanic response to divalproex, lithium, or placebo. Plasma GABA and urinary excretion of catecholamine metabolites were measured before randomization to lithium, divalproex or placebo in patients hospitalized for manic episodes. Severity of mania was evaluated using the Manic Syndrome, Behavior and Ideation and Mania Rating Scale scores from the SADS-C. Multiple regression analysis showed that pretreatment plasma GABA was related to severity of manic symptoms. This relationship seemed stronger in women. Multiple regression analysis showed that pretreatment levels of urinary MHPG correlated with improvement in manic syndrome scores. These data suggest that GABA and norepinephrine may be related to different aspects of the manic state and to its pharmacologic sensitivity. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-61 |
| Number of pages | 7 |
| Journal | Psychiatry Research |
| Volume | 88 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 18 1999 |
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Keywords
- Bipolar disorder
- GABA
- Lithium
- MHPG
- Norepinephrine
- Placebo
- Treatment outcome
- Valproate
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Mania : Gender, transmitter function, and response to treatment. / Swann, Alan C.; Petty, Frederick; Bowden, Charles L.; Dilsaver, Steven C.; Calabrese, Joseph R.; Morris, David D.
In: Psychiatry Research, Vol. 88, No. 1, 18.10.1999, p. 55-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mania
T2 - Gender, transmitter function, and response to treatment
AU - Swann, Alan C.
AU - Petty, Frederick
AU - Bowden, Charles L.
AU - Dilsaver, Steven C.
AU - Calabrese, Joseph R.
AU - Morris, David D.
PY - 1999/10/18
Y1 - 1999/10/18
N2 - Noradrenergic and GABA systems may be involved in mania, but there is little information about relationships between the function of these systems and response to specific antimanic treatments. We investigated relationships between indices of catecholamine or GABA system function, pretreatment mania severity and antimanic response to divalproex, lithium, or placebo. Plasma GABA and urinary excretion of catecholamine metabolites were measured before randomization to lithium, divalproex or placebo in patients hospitalized for manic episodes. Severity of mania was evaluated using the Manic Syndrome, Behavior and Ideation and Mania Rating Scale scores from the SADS-C. Multiple regression analysis showed that pretreatment plasma GABA was related to severity of manic symptoms. This relationship seemed stronger in women. Multiple regression analysis showed that pretreatment levels of urinary MHPG correlated with improvement in manic syndrome scores. These data suggest that GABA and norepinephrine may be related to different aspects of the manic state and to its pharmacologic sensitivity. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - Noradrenergic and GABA systems may be involved in mania, but there is little information about relationships between the function of these systems and response to specific antimanic treatments. We investigated relationships between indices of catecholamine or GABA system function, pretreatment mania severity and antimanic response to divalproex, lithium, or placebo. Plasma GABA and urinary excretion of catecholamine metabolites were measured before randomization to lithium, divalproex or placebo in patients hospitalized for manic episodes. Severity of mania was evaluated using the Manic Syndrome, Behavior and Ideation and Mania Rating Scale scores from the SADS-C. Multiple regression analysis showed that pretreatment plasma GABA was related to severity of manic symptoms. This relationship seemed stronger in women. Multiple regression analysis showed that pretreatment levels of urinary MHPG correlated with improvement in manic syndrome scores. These data suggest that GABA and norepinephrine may be related to different aspects of the manic state and to its pharmacologic sensitivity. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Bipolar disorder
KW - GABA
KW - Lithium
KW - MHPG
KW - Norepinephrine
KW - Placebo
KW - Treatment outcome
KW - Valproate
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U2 - 10.1016/S0165-1781(99)00069-4
DO - 10.1016/S0165-1781(99)00069-4
M3 - Article
C2 - 10641586
AN - SCOPUS:0032699090
VL - 88
SP - 55
EP - 61
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1
ER -