Mania: Gender, transmitter function, and response to treatment

Alan C. Swann, Frederick Petty, Charles L. Bowden, Steven C. Dilsaver, Joseph R. Calabrese, David D. Morris

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Noradrenergic and GABA systems may be involved in mania, but there is little information about relationships between the function of these systems and response to specific antimanic treatments. We investigated relationships between indices of catecholamine or GABA system function, pretreatment mania severity and antimanic response to divalproex, lithium, or placebo. Plasma GABA and urinary excretion of catecholamine metabolites were measured before randomization to lithium, divalproex or placebo in patients hospitalized for manic episodes. Severity of mania was evaluated using the Manic Syndrome, Behavior and Ideation and Mania Rating Scale scores from the SADS-C. Multiple regression analysis showed that pretreatment plasma GABA was related to severity of manic symptoms. This relationship seemed stronger in women. Multiple regression analysis showed that pretreatment levels of urinary MHPG correlated with improvement in manic syndrome scores. These data suggest that GABA and norepinephrine may be related to different aspects of the manic state and to its pharmacologic sensitivity. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalPsychiatry Research
Volume88
Issue number1
DOIs
StatePublished - Oct 18 1999

Keywords

  • Bipolar disorder
  • GABA
  • Lithium
  • MHPG
  • Norepinephrine
  • Placebo
  • Treatment outcome
  • Valproate

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Mania: Gender, transmitter function, and response to treatment'. Together they form a unique fingerprint.

Cite this