Management of women with a hereditary predisposition for breast cancer

Ismail Jatoi, John R. Benson

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Women with a hereditary breast cancer predisposition have three management options: screening, chemoprevention (risk-reducing medication) and risk-reducing surgery. However, no randomized trials have addressed the effect of these strategies in mutation carriers. In the general population, randomized trials failed to demonstrate a benefit for screening in premenopausal women. Moreover, although chemoprevention reduces breast cancer incidence in high-risk populations, this benefit is potentially confined to estrogen receptor-positive tumors. Finally, observational studies suggest that prophylactic mastectomy and even prophylactic salpingo-ophorectomy reduces breast cancer risk in BRCA mutation carriers, but there are systematic biases associated with such studies. Therefore, women with a hereditary predisposition for breast cancer should be informed of the three risk-reducing strategies, and that their benefits are not fully understood.

Original languageEnglish (US)
Pages (from-to)2277-2288
Number of pages12
JournalFuture Oncology
Issue number19
StatePublished - Oct 2016


  • Breast cancer
  • Chemoprevention
  • Genetic testing
  • Hereditary predisposition
  • Prophylactic surgery
  • Screening

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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