TY - JOUR
T1 - Management of Women Who Have a Genetic Predisposition for Breast Cancer
AU - Jatoi, Ismail
AU - Anderson, William F.
N1 - Funding Information:
This research was supported in part by the Intramural Research Program of the National Institutes of Health/National Cancer Institute.
PY - 2008/8
Y1 - 2008/8
N2 - The management of women who have a genetic predisposition for breast cancer requires careful planning. Women who have BRCA 1 and BRCA 2 mutations are at increased risk for breast cancer and for other cancers as well, particularly ovarian cancer. Screening, prophlyactic surgery, and chemoprevention are commonly utilized strategies in the management of these patients, and women may choose more than one of these strategies. No randomized prospective trials have assessed the impact of these strategies specifically in mutaiton carriers. All patients should be informed that screening, prophylactic surgery, and chemoprevention have the potential for harm as well as benefit.
AB - The management of women who have a genetic predisposition for breast cancer requires careful planning. Women who have BRCA 1 and BRCA 2 mutations are at increased risk for breast cancer and for other cancers as well, particularly ovarian cancer. Screening, prophlyactic surgery, and chemoprevention are commonly utilized strategies in the management of these patients, and women may choose more than one of these strategies. No randomized prospective trials have assessed the impact of these strategies specifically in mutaiton carriers. All patients should be informed that screening, prophylactic surgery, and chemoprevention have the potential for harm as well as benefit.
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U2 - 10.1016/j.suc.2008.04.007
DO - 10.1016/j.suc.2008.04.007
M3 - Review article
C2 - 18672143
AN - SCOPUS:48049113484
SN - 0039-6109
VL - 88
SP - 845
EP - 861
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 4
ER -