Management of anhedonia after epilepsy surgery

Gerardo Maria de Araujo Filho, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review


Anhedonia is clinically defined as difficulty or inability to feel pleasure or to be motivated to perform activities that were previously pleasurable. Anhedonia is a core feature of depressive disorders but can be present in other conditions such as substance use and anxiety disorders. Herein we report the case of a 34-year-old female who developed marked anhedonia after left cortico-amygdalohippocampectomy. Despite optimal seizure control, the person struggled with anhedonia and other depressive symptoms. After ruling out medico-neurologic complications, she was prescribed with a selective serotonin reuptake inhibitor and cognitive-behavioral therapy. Anhedonia can be a challenging neuropsychiatric presentation that requires ruling out the effects of antiseizure medications, neurosurgery, and other drugs before prescribing antidepressants.

Original languageEnglish (US)
Article number100658
JournalEpilepsy and Behavior Reports
StatePublished - Jan 2024


  • Anhedonia
  • Depression
  • Epilepsy Surgery
  • Selective Serotonin Reuptake Inhibitor
  • Temporal Lobe Epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Behavioral Neuroscience


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