TY - JOUR
T1 - Management of androgen deprivation therapy-associated hot flashes in men with prostate cancer
AU - Qan'ir, Yousef
AU - DeDeaux, Darrell
AU - Godley, Paul A.
AU - Mayer, Deborah K.
AU - Song, Lixin
N1 - Funding Information:
School of Nursing at the University of North Carolina at Chapel Hill; Darrell DeDeaux, MNP, is a nurse practitioner at Campbell University Health Center in Lillington, NC; and Paul A. Godley, MD, PhD, MPP, was the Rush S. Dickson Distinguished Professor of Hematology/Oncology in the Department of Medicine and a medical oncologist in the Lineberger Comprehensive Cancer Center, Deborah K. Mayer, PhD, RN, AOCN®, FAAN, is a Frances Hill Fox Distinguished Professor of Nursing in the School of Nursing and the director of the Cancer Survivorship program in the Lineberger Comprehensive Cancer Center, and Lixin Song, PhD, is an associate professor and the Beerstecher-Blackwell Distinguished Term Scholar in the School of Nursing and in the Lineberger Comprehensive Cancer Center, all at the University of North Carolina at Chapel Hill. Song can be reached at lsong@unc.edu, with copy to ONFEditor@ons.org. (Submitted October 2018. Accepted February 11, 2019.) This research was funded by a university cancer research fund (principal investigator: Song) from the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill.
Publisher Copyright:
© 2019 Oncology Nursing Society. All rights reserved.
PY - 2019
Y1 - 2019
N2 - PROBLEM IDENTIFICATION: To determine best practices for managing hot flashes associated with androgen deprivation therapy (ADT) in men with prostate cancer. LITERATURE SEARCH: The CINAHL®, Embase®, PsycINFO®, PubMed®, and Scopus® databases were used to identify randomized controlled trials (RCTs) and quasiexperimental studies published between January 1994 and June 2018. DATA EVALUATION: Using the Cochrane Handbook for Systematic Reviews of Interventions, the authors reviewed 15 studies examining the effects of pharmacologic or complementary and alternative medicine interventions on ADT-associated hot flashes in men with prostate cancer. SYNTHESIS: Pharmacologic interventions (e.g., cyproterone, medroxyprogesterone, megestrol acetate) showed some promise for reducing hot flashes but were associated with side effects and risks. Acupuncture demonstrated potential benefit in reducing hot flashes without side effects. IMPLICATIONS FOR RESEARCH: Evidence is insufficient to support interventions for ADTassociated hot flashes in men with prostate cancer. Future RCTs should be sufficiently powered, include a control group, and use standardized outcome measures.
AB - PROBLEM IDENTIFICATION: To determine best practices for managing hot flashes associated with androgen deprivation therapy (ADT) in men with prostate cancer. LITERATURE SEARCH: The CINAHL®, Embase®, PsycINFO®, PubMed®, and Scopus® databases were used to identify randomized controlled trials (RCTs) and quasiexperimental studies published between January 1994 and June 2018. DATA EVALUATION: Using the Cochrane Handbook for Systematic Reviews of Interventions, the authors reviewed 15 studies examining the effects of pharmacologic or complementary and alternative medicine interventions on ADT-associated hot flashes in men with prostate cancer. SYNTHESIS: Pharmacologic interventions (e.g., cyproterone, medroxyprogesterone, megestrol acetate) showed some promise for reducing hot flashes but were associated with side effects and risks. Acupuncture demonstrated potential benefit in reducing hot flashes without side effects. IMPLICATIONS FOR RESEARCH: Evidence is insufficient to support interventions for ADTassociated hot flashes in men with prostate cancer. Future RCTs should be sufficiently powered, include a control group, and use standardized outcome measures.
KW - Androgen deprivation therapy
KW - Complementary and alternative medicine
KW - Hot flashes
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U2 - 10.1188/19.ONF.E107-E118
DO - 10.1188/19.ONF.E107-E118
M3 - Review article
C2 - 31225840
AN - SCOPUS:85068495488
SN - 0190-535X
VL - 46
SP - E107-E118
JO - Oncology Nursing Forum
JF - Oncology Nursing Forum
IS - 4
ER -