Malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma): An electron microscopic study

Robert L. Reddick, Herman Michelitch, Timothy J. Triche

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

A comparative ultrastructural analysis of malignant soft tissue tumors (malignant fibrous histiocytoma, pleomorphic liposarcoma, and pleomorphic rhabdomyosarcoma) revealed similar ultrastructural features in this group of tumors. However, by electron microscopy these tumors can be differentiated on the basis of cytoplasmic and extracytoplasmic features (myosin filaments, lipid droplests and perinuclear intermediate filaments, for example). This is even true of less well differentiated tumors and tumor cells. These findings support and amplify the concept of a common histogenesis for tumors of mesenchymal origin. Paradoxical features observed by light microscopy wasrant further study by electron microscopy if the correct diagnosis is to be made in atypical cases, such as apparent malignant fibrous histiocytoma with cross striations.

Original languageEnglish (US)
Pages (from-to)327-343
Number of pages17
JournalHuman Pathology
Volume10
Issue number3
DOIs
StatePublished - May 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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