Malignant mesothelioma: Prognostic variables in a registry of 180 patients, the Dana-Farber Cancer Institute and Brigham and Women's Hospital experience over two decades, 1965-1985

K. Antman, R. Shemin, L. Ryan, K. Klegar, R. Osteen, T. Herman, G. Lederman, J. Corson

Research output: Contribution to journalArticlepeer-review

251 Scopus citations

Abstract

All mesothelioma patients identified by a computer search of pathologic diagnoses at the Dana-Farber Cancer Institute (DFCI) between 1965 and 1985 were the subjects of this analysis. A total of 180 patients were identified, 136 with pleural and 37 with peritoneal mesothelioma. There were five pericardial and two testicular primaries. Of the two decades included in the study, later patients were significantly older, with a more advanced disease stage, and a lower performance status than those accrued early in the study. Factors at diagnosis associated with a significantly prolonged survival for all patients with mesothelioma included a 0 to 1 performance status, absence of chest pain, age <50 years, and epithelial histology. Factors at diagnosis associated with pleural mesothelioma included epithelial histology, 0 to 1 performance status, the absence of chest pain, an interval of >6 months from onset of symptoms, and treatment with chemotherapy and pleuropneumonectomy. This last result must be interpreted with caution, since this was not a randomized study.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalJournal of Clinical Oncology
Volume6
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Malignant mesothelioma: Prognostic variables in a registry of 180 patients, the Dana-Farber Cancer Institute and Brigham and Women's Hospital experience over two decades, 1965-1985'. Together they form a unique fingerprint.

Cite this