Malignant disorders of megakaryocytes

L. D. Cripe, R. Hromas

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Among hematologic malignancies, there are three disorders whose behavior is governed principally by the abnormal proliferation of a malignant megakaryocytic clone or a product thereof. These disorders are essential thrombocythemia, agnogenic myeloid metaplasia, and acute megakaryoblastic leukemia. Although there are other myeloproliferative diseases that can have high platelet counts, the major pathobiology of those diseases most commonly results from the proliferation of other hematopoietic lineages. Despite the rarity of the three disorders of malignant megakaryopoiesis mentioned above, advances have been made in the diagnosis, prognosis, and treatment of these disorders in recent years. However, understanding of the cellular and especially molecular pathobiology lags far behind.

Original languageEnglish (US)
Pages (from-to)200-209
Number of pages10
JournalSeminars in Hematology
Issue number3
StatePublished - Jul 31 1998
Externally publishedYes

ASJC Scopus subject areas

  • Hematology


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