Malignancy-associated pulmonary veno-occlusive disease: Report of a case following autologous bone marrow transplantation and review

D. Salzman, D. R. Adkins, F. Craig, C. Freytes, C. F. LeMaistre

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Pulmonary veno-occlusive disease (VOD) is a rare cause of pulmonary hypertension (HTN) which has been described in association with a variety of clinical conditions. Rapidly progressive occlusion of pulmonary veins and venules develops that is usually fatal. Recently, a number of cases have been reported in patients with malignancies. To date, 33 patients have developed pulmonary VOD in association with a malignancy or after chemotherapy and/or radiation therapy. Two-thirds of the cases occurred following allogeneic bone marrow transplantation (BMT). We describe the first case of pulmonary VOD following autologous BMT and review the experience of pulmonary VOD in patients with malignancies.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalBone Marrow Transplantation
Volume18
Issue number4
StatePublished - Oct 1 1996

Keywords

  • Bone marrow transplantation
  • Malignancy
  • Pulmonary VOD

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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