Malignancy and the skeleton

G. R. Mundy

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Bone is one of the three most common sites of tumor metastasis. Bone metastasis is a catastrophic complication of cancer, since it is not only associated with intractable pain, but also with other morbidity such as hypercalcemia which usually hastens an uncomfortable death. Despite the importance of bone metastasis/hypercalcemia, until recently clinicians have used specific therapies only for the treatment of hypercalcemia but not for bone metastasis. During this presentation, I will review our current understanding of some of the steps involved in the pathophysiology of bone metastasis and its association with hypercalcemia, and how I think these complications of cancer should be treated.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalHormone and Metabolic Research
Issue number3
StatePublished - 1997


  • bone
  • cancer
  • hypercalcemia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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