Making the jump: New insights into the mechanism of trans-translation

Jacek Wower; Iwona K. Wower; Christian Zwieb

doi:10.1186/jbiol78

Making the jump: New insights into the mechanism of trans-translation

Jacek Wower, Iwona K. Wower, Christian Zwieb

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.

Original language	English (US)
Article number	17
Journal	Journal of Biology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1186/jbiol78
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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10.1186/jbiol78

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title = "Making the jump: New insights into the mechanism of trans-translation",

abstract = "The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.",

author = "Jacek Wower and Wower, {Iwona K.} and Christian Zwieb",

note = "Funding Information: The authors were supported by grants GM58267 and GM49034 from the NIH. We dedicate this work to the late Twix.",

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AU - Zwieb, Christian

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AB - The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.

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Making the jump: New insights into the mechanism of trans-translation

Abstract

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