Making the jump: New insights into the mechanism of trans-translation

Jacek Wower, Iwona K. Wower, Christian Zwieb

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.

Original languageEnglish (US)
Article number17
JournalJournal of Biology
Issue number5
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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