Making the jump: New insights into the mechanism of trans-translation

Jacek Wower, Iwona K. Wower, Christian W Zwieb

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.

Original languageEnglish (US)
Article number17
JournalJournal of Biology
Volume7
Issue number5
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

ribosomes
Ribosomes
translation (genetics)
ribonucleoproteins
Terminator Codon
stop codon
protein degradation
Proteolysis
Proteins
proteins
RNA
Biological Sciences
Degradation
Messenger RNA
tmRNA
small protein B
messenger ribonucleoprotein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Making the jump : New insights into the mechanism of trans-translation. / Wower, Jacek; Wower, Iwona K.; Zwieb, Christian W.

In: Journal of Biology, Vol. 7, No. 5, 17, 2008.

Research output: Contribution to journalArticle

Wower, Jacek ; Wower, Iwona K. ; Zwieb, Christian W. / Making the jump : New insights into the mechanism of trans-translation. In: Journal of Biology. 2008 ; Vol. 7, No. 5.
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