Abstract
Subcellular organization for the separation of biochemical processes is critically important for facilitating and maintaining cell functions. Membrane-less organelles (MLOs), subcellular structures that are formed by biomolecular interactions that drive liquid–liquid phase separation, are dense phases highly concentrated in proteins and nucleic acids that include or exclude a specific subset of biomolecules and metabolites. The structural properties inherent to the macromolecule(s) that participate in MLO formation determine the organization and structure of the dense phase by modulating the liquid to solid transition of the condensate. Furthermore, the interactions between the constituent members of the condensate define the organization of the structure and determine the properties and liquidness of the outer and inner layers influencing the overall function and stability of the MLO. Therefore, it is important to understand the interplay of the properties of proteins and nucleic acids that contribute to the diversity of MLOs organization.
Original language | English (US) |
---|---|
Title of host publication | Droplets of Life |
Subtitle of host publication | Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation |
Publisher | Elsevier |
Pages | 83-99 |
Number of pages | 17 |
ISBN (Electronic) | 9780128239674 |
ISBN (Print) | 9780128241752 |
DOIs | |
State | Published - Jan 1 2022 |
Keywords
- Biophysics
- Liquid–liquid phase separation
- Membrane-less organelle
- Properties of biomolecules
- Structural classification of proteins
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology