TY - JOUR
T1 - Major gene for percent of oxygen saturation of arterial hemoglobin in Tibetan highlanders
AU - Beall, Cynthia M.
AU - Blangero, John
AU - Williams‐Blangero, Sarah
AU - Goldstein, Melvyn C.
PY - 1994/11
Y1 - 1994/11
N2 - This report employs a statistical genetic approach to analyze quantitative oxygen transport variables in a high‐altitude (4,850–5,450 m) native Tibetan population and demonstrates the presence of a major gene influencing % O2 saturation of arterial hemoglobin. This result suggests the hypothesis that individuals with the dominant allele for higher % O2 saturation have a selective advantage at high altitude. Studies of the biologically distinctive Himalayan and Andean populations have greatly influenced thinking about ongoing human evolution and adaptation; this is the first statistical evidence for a major gene enhancing oxygen transport in a highaltitude native population. © 1994 wiley‐Liss, Inc.
AB - This report employs a statistical genetic approach to analyze quantitative oxygen transport variables in a high‐altitude (4,850–5,450 m) native Tibetan population and demonstrates the presence of a major gene influencing % O2 saturation of arterial hemoglobin. This result suggests the hypothesis that individuals with the dominant allele for higher % O2 saturation have a selective advantage at high altitude. Studies of the biologically distinctive Himalayan and Andean populations have greatly influenced thinking about ongoing human evolution and adaptation; this is the first statistical evidence for a major gene enhancing oxygen transport in a highaltitude native population. © 1994 wiley‐Liss, Inc.
KW - Adaptation
KW - Hypoxia
KW - Statistical genetics
KW - Tibet
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U2 - 10.1002/ajpa.1330950303
DO - 10.1002/ajpa.1330950303
M3 - Article
C2 - 7856765
AN - SCOPUS:0028125214
VL - 95
SP - 271
EP - 276
JO - American Journal of Physical Anthropology
JF - American Journal of Physical Anthropology
SN - 0002-9483
IS - 3
ER -