Major gene for percent of oxygen saturation of arterial hemoglobin in Tibetan highlanders

Cynthia M. Beall, John Blangero, Sarah Williams‐Blangero, Melvyn C. Goldstein

    Research output: Contribution to journalArticle

    68 Scopus citations

    Abstract

    This report employs a statistical genetic approach to analyze quantitative oxygen transport variables in a high‐altitude (4,850–5,450 m) native Tibetan population and demonstrates the presence of a major gene influencing % O2 saturation of arterial hemoglobin. This result suggests the hypothesis that individuals with the dominant allele for higher % O2 saturation have a selective advantage at high altitude. Studies of the biologically distinctive Himalayan and Andean populations have greatly influenced thinking about ongoing human evolution and adaptation; this is the first statistical evidence for a major gene enhancing oxygen transport in a highaltitude native population. © 1994 wiley‐Liss, Inc.

    Original languageEnglish (US)
    Pages (from-to)271-276
    Number of pages6
    JournalAmerican Journal of Physical Anthropology
    Volume95
    Issue number3
    DOIs
    StatePublished - Nov 1994

    Keywords

    • Adaptation
    • Hypoxia
    • Statistical genetics
    • Tibet

    ASJC Scopus subject areas

    • Anatomy
    • Anthropology

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