Major depressive disorder and disease activity in systemic lupus erythematosus

Fabiano G. Nery, Eduardo F. Borba, John P. Hatch, Jair C. Soares, Eloísa Bonfá, Francisco Lotufo Neto

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

The association between psychosocial factors and systemic lupus erythematosus (SLE) is still a matter of discussion. Mood disorders may represent neuropsychiatric manifestations of SLE disease activity or may be a consequence of the stress of having a chronic major disease. We examined the hypothesis that SLE disease activity is related to the presence and severity of major depression in patients with SLE. Seventy-one patients with SLE were evaluated for the presence and intensity of major depressive disorder, psychosocial stressors, functional disability, SLE disease activity, and cumulative damage. Patients with major depression presented a trend toward having greater severity of SLE disease activity compared with those without major depression (P = .056). Major depression was also associated with life events (P = .017) and hassles (P < .001). Reinforcing these findings, depression severity was directly correlated with disease activity (r = 0.26, P = .026) and with functional disability (r = 0.46, P < .001). Moreover, multiple linear regression analysis, controlling for stressful life events and previous major depressive episodes, demonstrated that SLE disease activity still was associated with depression severity (P = .014). In conclusion, these results support the hypothesis that SLE disease activity is a potential risk factor for the presence and severity of major depression in patients with SLE. Whether major depression in active SLE is a central nervous system manifestation of the disease that is mediated by an autoimmune mechanism deserves further research.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalComprehensive Psychiatry
Volume48
Issue number1
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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    Nery, F. G., Borba, E. F., Hatch, J. P., Soares, J. C., Bonfá, E., & Neto, F. L. (2007). Major depressive disorder and disease activity in systemic lupus erythematosus. Comprehensive Psychiatry, 48(1), 14-19. https://doi.org/10.1016/j.comppsych.2006.04.002