Abstract
Background and Objectives: A novel method to detect tissue-based macrophages using a combination of super-paramagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. Study Design/Material and Methods: Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. Results: Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. Conclusions: Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field.
Original language | English (US) |
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Pages (from-to) | 266-272 |
Number of pages | 7 |
Journal | Lasers in Surgery and Medicine |
Volume | 39 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2007 |
Keywords
- Differential phase optical coherence tomography (DP-OCT)
- Macrophages
- Magnetic flux density
- Superparamagnetic iron oxide nanoparticles (SPIO)
ASJC Scopus subject areas
- Surgery
- Dermatology