Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography

Junghwan Oh, Marc D. Feldman, Jihoon Kim, Hyun Wook Kang, Pramod Sanghi, Thomas E. Milner

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Background and Objectives: A novel method to detect tissue-based macrophages using a combination of super-paramagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. Study Design/Material and Methods: Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. Results: Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. Conclusions: Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field.

Original languageEnglish (US)
Pages (from-to)266-272
Number of pages7
JournalLasers in Surgery and Medicine
Volume39
Issue number3
DOIs
StatePublished - Mar 1 2007

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Keywords

  • Differential phase optical coherence tomography (DP-OCT)
  • Macrophages
  • Magnetic flux density
  • Superparamagnetic iron oxide nanoparticles (SPIO)

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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