Magnetic resonance spectroscopy of inflammation associated with the temporomandibular joint

M. E. Alder, S. B. Dove, V. A. Murrah, F. Salinas, R. F. Williams

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Noninvasive early recognition and treatment of temporomandibular joint dysfunction remains a diagnostic challenge. This pilot study evaluated the use of phosphorus 31 magnetic resonance spectroscopy with magnetic resonance imaging to measure alterations in pH and high-energy phosphate metabolite ratios of muscle that is adjacent to an inflamed temporomandibular joint. Ten New Zealand white rabbits were used in this study. Two animals were used to develop signal acquisition protocols and to ensure that stable baseline data could be measured. In each of the eight animals used in the experiment, one temporomandibular joint was injected with a suspension of silica particles and the contralateral joint served as a control. Data were collected from control and experimental joints on days 0, 7, 14, 21, and 28, after the injection. At the end of the study, temporomandibular joints were block resected and histologically examined to confirm the presence of an inflammatory response. Results indicated that pH and metabolite ratios could be obtained by 31P-magnetic resonance spectroscopy. Changes in pH and some metabolite ratios in experimental joints showed statistical significance (p < 0.001). Differences were seen on day 2 and day 7 (p = 0.040 and p = 0.008, respectively) in the phosphocreatine/α-adenosine triphosphate ratios. This contrasts with phosphocreatine/β adenosine triphosphate ratios that showed significance that began at day 7 (p = 0.022) and continued to day 14 (p = 0.025). Histologic examination indicated that the tissue response within the joint capsule was less than the granulomatous reaction expected. This pilot study clearly demonstrates that pH changes that occur in muscle that is adjacent to an inflamed joint are detectable by 31P-magnetic resonance spectroscopy.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology
Volume74
Issue number4
DOIs
StatePublished - 1992

Fingerprint

Temporomandibular Joint
Magnetic Resonance Spectroscopy
Joints
Inflammation
Phosphocreatine
Adenosine Triphosphate
Joint Capsule
Muscles
Silicon Dioxide
Phosphorus
Suspensions
Phosphates
Magnetic Resonance Imaging
Rabbits
Injections
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Magnetic resonance spectroscopy of inflammation associated with the temporomandibular joint. / Alder, M. E.; Dove, S. B.; Murrah, V. A.; Salinas, F.; Williams, R. F.

In: Oral Surgery, Oral Medicine, Oral Pathology, Vol. 74, No. 4, 1992, p. 515-523.

Research output: Contribution to journalArticle

Alder, M. E. ; Dove, S. B. ; Murrah, V. A. ; Salinas, F. ; Williams, R. F. / Magnetic resonance spectroscopy of inflammation associated with the temporomandibular joint. In: Oral Surgery, Oral Medicine, Oral Pathology. 1992 ; Vol. 74, No. 4. pp. 515-523.
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