Magnetic resonance imaging in tuberous sclerosis

E. S. Roach, D. P. Williams, D. W. Laster

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Twenty-five patients with tuberous sclerosis were studied with magnetic resonance imaging (MRI), and these findings were compared with those of computed cranial tomography (CCT) and with the clinical severity of the disease. Multiple high-signal MRI lesions involving the cerebral cortex are characteristic of tuberous sclerosis and probably correspond to the hamartomas and gliotic areas seen pathologically. These cortical lesions were only occasionally seen with CCT. The periventricular calcific lesions characteristic of tuberous sclerosis are better visualized with CCT than with MRI, but the larger periventricular calcifications produce low-signal MRI abnormalities. Seven patients had high-signal MRI lesions of the cerebellum; small calcific cerebellar lesions were also noted with CCT in three patients. As in earlier studies, no clear correlation was seen between the number of abnormalities visible CCT and the clinical severity of the disease. By contrast, the more severely affected patients tend to have a higher number of cerebral cortical lesions detected with MRI. Thus, MRI may be useful in predicting the eventual clinical severity of younger children with newly diagnosed tuberous sclerosis.

Original languageEnglish (US)
Pages (from-to)301-303
Number of pages3
JournalArchives of Neurology
Volume44
Issue number3
StatePublished - 1987
Externally publishedYes

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Tuberous Sclerosis
Magnetic Resonance Imaging
Tomography
Hamartoma
Cerebral Cortex
Cerebellum
Lesion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Roach, E. S., Williams, D. P., & Laster, D. W. (1987). Magnetic resonance imaging in tuberous sclerosis. Archives of Neurology, 44(3), 301-303.

Magnetic resonance imaging in tuberous sclerosis. / Roach, E. S.; Williams, D. P.; Laster, D. W.

In: Archives of Neurology, Vol. 44, No. 3, 1987, p. 301-303.

Research output: Contribution to journalArticle

Roach, ES, Williams, DP & Laster, DW 1987, 'Magnetic resonance imaging in tuberous sclerosis', Archives of Neurology, vol. 44, no. 3, pp. 301-303.
Roach ES, Williams DP, Laster DW. Magnetic resonance imaging in tuberous sclerosis. Archives of Neurology. 1987;44(3):301-303.
Roach, E. S. ; Williams, D. P. ; Laster, D. W. / Magnetic resonance imaging in tuberous sclerosis. In: Archives of Neurology. 1987 ; Vol. 44, No. 3. pp. 301-303.
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