Magnetic resonance imaging in experimental traumatic brain injury

Qiang Shen, Lora Tally Watts, Wei Li, Timothy Q. Duong

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability in the USA. Common causes of TBI include falls, violence, injuries from wars, and vehicular and sporting accidents. The initial direct mechanical damage in TBI is followed by progressive secondary injuries such as brain swelling, perturbed cerebral blood flow (CBF), abnormal cerebrovascular reactivity (CR), metabolic dysfunction, blood–brain-barrier disruption, inflammation, oxidative stress, and excitotoxicity, among others. Magnetic resonance imaging (MRI) offers the means to noninvasively probe many of these secondary injuries. MRI has been used to image anatomical, physiological, and functional changes associated with TBI in a longitudinal manner. This chapter describes controlled cortical impact (CCI) TBI surgical procedures, a few common MRI protocols used in TBI imaging, and, finally, image analysis pertaining to experimental TBI imaging in rats.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press
Pages645-658
Number of pages14
Volume1462
DOIs
StatePublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1462
ISSN (Print)10643745

Keywords

  • ADC
  • BBB
  • CBF
  • DWI
  • Experimental TBI model
  • fMRI
  • MRI
  • PWI
  • Rodents
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics

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  • Cite this

    Shen, Q., Watts, L. T., Li, W., & Duong, T. Q. (2016). Magnetic resonance imaging in experimental traumatic brain injury. In Methods in Molecular Biology (Vol. 1462, pp. 645-658). (Methods in Molecular Biology; Vol. 1462). Humana Press. https://doi.org/10.1007/978-1-4939-3816-2_35