Caracterizacion imagenologica de la enfermedad de Alzheimer asociada a la mutacion E280A-PS1. Estudio caso-control: Hallazgos en la resonancia magnetica

Translated title of the contribution: Magnetic resonance image characterization of early onset Alzheimer disease associated to E280A-PS1 mutation. Case-control study: Findings in the magnetic resonance image

F. Lopera, N. Tobón, M. Arcos-Burgos, S. Vargas, J. E. Gutiérrez, M. Rosselli, A. Ardila

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction and methods. In order to compare the magnetic resonance image characteristics of individuals belonging to pedigrees carrying the mutation E280A-PS1 associated to early onset Alzheimer disease, coming from Antioquia, Colombia, 78 individuals were studied. 47 of them were carriers of the mutation, 23 of those presented symptoms and 31 individuals being controls (non carriers of the mutation). Results. In summary, significative differences were appreciated between symptomatic individuals and those asymptomatic. There was not significant difference between asymptomatic carriers and the controls. The presence of the perihippocampal fissure constituted a difference statistically significant between the symptomatic individuals and those carriers asymptomatic and between the symptomatic ones and the controls. The interuncal distance increased significantly was another difference between symptomatic and asymptomatic individuals and among symptomatic and control group. The lobar atrophy and the ventriculomegaly were found in symptomatic individuals and they correlate with the disorder graveness. There was not significance in the presence of infarcts and/or hippocampal hyperintensities. Conclusion. These results corroborate the statement that magnetic resonance image is very useful in the diagnosis and pursuing of individuals affected by early onset Alzheimer disease.

Original languageSpanish
Pages (from-to)6-12
Number of pages7
JournalRevista de Neurologia
Volume29
Issue number1
StatePublished - Jul 1 1999
Externally publishedYes

Fingerprint

Case-Control Studies
Alzheimer Disease
Magnetic Resonance Spectroscopy
Mutation
Colombia
Pedigree
Atrophy
Control Groups

Keywords

  • Alzheimer disease
  • Antioquia
  • Colombia
  • Dementia
  • Early onset Alzheimer disease
  • Genetics
  • Magnetic resonance image
  • Presenilin 1

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lopera, F., Tobón, N., Arcos-Burgos, M., Vargas, S., Gutiérrez, J. E., Rosselli, M., & Ardila, A. (1999). Caracterizacion imagenologica de la enfermedad de Alzheimer asociada a la mutacion E280A-PS1. Estudio caso-control: Hallazgos en la resonancia magnetica. Revista de Neurologia, 29(1), 6-12.

Caracterizacion imagenologica de la enfermedad de Alzheimer asociada a la mutacion E280A-PS1. Estudio caso-control : Hallazgos en la resonancia magnetica. / Lopera, F.; Tobón, N.; Arcos-Burgos, M.; Vargas, S.; Gutiérrez, J. E.; Rosselli, M.; Ardila, A.

In: Revista de Neurologia, Vol. 29, No. 1, 01.07.1999, p. 6-12.

Research output: Contribution to journalArticle

Lopera, F, Tobón, N, Arcos-Burgos, M, Vargas, S, Gutiérrez, JE, Rosselli, M & Ardila, A 1999, 'Caracterizacion imagenologica de la enfermedad de Alzheimer asociada a la mutacion E280A-PS1. Estudio caso-control: Hallazgos en la resonancia magnetica', Revista de Neurologia, vol. 29, no. 1, pp. 6-12.
Lopera, F. ; Tobón, N. ; Arcos-Burgos, M. ; Vargas, S. ; Gutiérrez, J. E. ; Rosselli, M. ; Ardila, A. / Caracterizacion imagenologica de la enfermedad de Alzheimer asociada a la mutacion E280A-PS1. Estudio caso-control : Hallazgos en la resonancia magnetica. In: Revista de Neurologia. 1999 ; Vol. 29, No. 1. pp. 6-12.
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