Macrophages on intrauterine contraceptive devices produce prostaglandins

L. Myatt, M. A. Bray, D. Gordon, J. Morley

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

THE mechanisms whereby intrauterine contraceptive devices (IUDs) exert their anti-fertility effects remains unestablished1. The involvement of prostaglandins (PGs) is being investigated2-5, although alternative mechanisms have been proposed (for example, phagocytic and other actions of macrophages6,7). Although the relative contributions of macrophages and PGs to the anti-fertility actions of IUDs remains uncertain, it is clear that introduction of the IUD into the endometrial cavity results in an infiltration by neutrophils and macrophages8 as well as increased PG levels in uterine venous blood in animals9,10. While investigating the role of mediators of chronic inflammation we have demonstrated that the macrophage is a potent source of PGE11, and since the macrophage is the predominant cell adhering to the IUD6 we have considered the possibility that such cells act as a source of PGs.

Original languageEnglish (US)
Pages (from-to)227-228
Number of pages2
JournalNature
Volume257
Issue number5523
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Intrauterine Devices
Prostaglandins
Macrophages
Fertility Agents
Inflammation Mediators
Neutrophil Infiltration
Fertility

ASJC Scopus subject areas

  • General

Cite this

Myatt, L., Bray, M. A., Gordon, D., & Morley, J. (1975). Macrophages on intrauterine contraceptive devices produce prostaglandins. Nature, 257(5523), 227-228. https://doi.org/10.1038/257227a0

Macrophages on intrauterine contraceptive devices produce prostaglandins. / Myatt, L.; Bray, M. A.; Gordon, D.; Morley, J.

In: Nature, Vol. 257, No. 5523, 1975, p. 227-228.

Research output: Contribution to journalArticle

Myatt, L, Bray, MA, Gordon, D & Morley, J 1975, 'Macrophages on intrauterine contraceptive devices produce prostaglandins', Nature, vol. 257, no. 5523, pp. 227-228. https://doi.org/10.1038/257227a0
Myatt, L. ; Bray, M. A. ; Gordon, D. ; Morley, J. / Macrophages on intrauterine contraceptive devices produce prostaglandins. In: Nature. 1975 ; Vol. 257, No. 5523. pp. 227-228.
@article{4f0d588acfb64459aed16e8d7c070402,
title = "Macrophages on intrauterine contraceptive devices produce prostaglandins",
abstract = "THE mechanisms whereby intrauterine contraceptive devices (IUDs) exert their anti-fertility effects remains unestablished1. The involvement of prostaglandins (PGs) is being investigated2-5, although alternative mechanisms have been proposed (for example, phagocytic and other actions of macrophages6,7). Although the relative contributions of macrophages and PGs to the anti-fertility actions of IUDs remains uncertain, it is clear that introduction of the IUD into the endometrial cavity results in an infiltration by neutrophils and macrophages8 as well as increased PG levels in uterine venous blood in animals9,10. While investigating the role of mediators of chronic inflammation we have demonstrated that the macrophage is a potent source of PGE11, and since the macrophage is the predominant cell adhering to the IUD6 we have considered the possibility that such cells act as a source of PGs.",
author = "L. Myatt and Bray, {M. A.} and D. Gordon and J. Morley",
year = "1975",
doi = "10.1038/257227a0",
language = "English (US)",
volume = "257",
pages = "227--228",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5523",

}

TY - JOUR

T1 - Macrophages on intrauterine contraceptive devices produce prostaglandins

AU - Myatt, L.

AU - Bray, M. A.

AU - Gordon, D.

AU - Morley, J.

PY - 1975

Y1 - 1975

N2 - THE mechanisms whereby intrauterine contraceptive devices (IUDs) exert their anti-fertility effects remains unestablished1. The involvement of prostaglandins (PGs) is being investigated2-5, although alternative mechanisms have been proposed (for example, phagocytic and other actions of macrophages6,7). Although the relative contributions of macrophages and PGs to the anti-fertility actions of IUDs remains uncertain, it is clear that introduction of the IUD into the endometrial cavity results in an infiltration by neutrophils and macrophages8 as well as increased PG levels in uterine venous blood in animals9,10. While investigating the role of mediators of chronic inflammation we have demonstrated that the macrophage is a potent source of PGE11, and since the macrophage is the predominant cell adhering to the IUD6 we have considered the possibility that such cells act as a source of PGs.

AB - THE mechanisms whereby intrauterine contraceptive devices (IUDs) exert their anti-fertility effects remains unestablished1. The involvement of prostaglandins (PGs) is being investigated2-5, although alternative mechanisms have been proposed (for example, phagocytic and other actions of macrophages6,7). Although the relative contributions of macrophages and PGs to the anti-fertility actions of IUDs remains uncertain, it is clear that introduction of the IUD into the endometrial cavity results in an infiltration by neutrophils and macrophages8 as well as increased PG levels in uterine venous blood in animals9,10. While investigating the role of mediators of chronic inflammation we have demonstrated that the macrophage is a potent source of PGE11, and since the macrophage is the predominant cell adhering to the IUD6 we have considered the possibility that such cells act as a source of PGs.

UR - http://www.scopus.com/inward/record.url?scp=0016774780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016774780&partnerID=8YFLogxK

U2 - 10.1038/257227a0

DO - 10.1038/257227a0

M3 - Article

VL - 257

SP - 227

EP - 228

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5523

ER -