Macrófagos, inflamación, tejido adiposo, obesidad y resistencia a la insulina

Translated title of the contribution: Macrophage, inflammation, adipose tissue, obesity and insulin resistance

Raúl A. Bastarrachea, Juan Carlos López-Alvarenga, Victoria Eugenia Bolado-García, Jorge Téllez-Mendoza, Hugo Laviada-Molina, Anthony G. Comuzzie

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Obesity is associated with a complex systemic inflammatory reaction that has been associated with the development of atherosclerosis and insulin resistance. Obesity also induces macrophage accumulation in adipose tissue. Macrophages produce many of the pro inflammatory molecules released by adipose tissue and have been implicated in the development of obesity-induced adipose tissue inflammation. Monocyte chemoattractant proteins (MCPs) and their receptors play key roles in the development of inflammatory responses and are crucial for the recruitment of immune cells towards inflammation sites . Adipose tissue expression of at least 1 MCP, C-C motif chemokine ligand-2 (CCL2 or MCP1), increases in proportion to adiposity. The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. Because CCR2 regulates monocyte and macrophage chemotaxis and local inflammatory responses, it has been hypothesized that monocyte chemoattractant molecules acting through CCR2 might regulate obesity-induced inflammation in adipose tissue. Our study focuses on the molecular and genetic mechanisms that recruit and retain macrophages in adipose tissue.

Translated title of the contributionMacrophage, inflammation, adipose tissue, obesity and insulin resistance
Original languageSpanish
Pages (from-to)505-512
Number of pages8
JournalGaceta Medica de Mexico
Issue number6
StatePublished - 2007
Externally publishedYes


  • Adipocite
  • Endothelial dysfunction
  • Inflammation
  • Insulin resistance
  • MCP1
  • Macrophage

ASJC Scopus subject areas

  • Medicine(all)


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