Machinations of a Maxwellian demon

Rui Sousa

doi:10.1016/j.cell.2005.01.003

Machinations of a Maxwellian demon

Rui Sousa

Biochemistry & Structural Biology

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The mechanisms by which RNA polymerase moves along DNA during elongation have been difficult to determine experimentally. In this issue of Cell, Bar-Nahum et al. (2005) show that back and forth sliding of RNA polymerase on DNA may be coupled to bending of an α helix, which can alternately occlude and expose the NTP binding site. Transcription factors can regulate elongation by modulating this bending motion.

Original language	English (US)
Pages (from-to)	155-156
Number of pages	2
Journal	Cell
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2005.01.003
State	Published - Jan 28 2005

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2005.01.003

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abstract = "The mechanisms by which RNA polymerase moves along DNA during elongation have been difficult to determine experimentally. In this issue of Cell, Bar-Nahum et al. (2005) show that back and forth sliding of RNA polymerase on DNA may be coupled to bending of an α helix, which can alternately occlude and expose the NTP binding site. Transcription factors can regulate elongation by modulating this bending motion.",

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