Machinations of a Maxwellian demon

Rui Sousa

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The mechanisms by which RNA polymerase moves along DNA during elongation have been difficult to determine experimentally. In this issue of Cell, Bar-Nahum et al. (2005) show that back and forth sliding of RNA polymerase on DNA may be coupled to bending of an α helix, which can alternately occlude and expose the NTP binding site. Transcription factors can regulate elongation by modulating this bending motion.

Original languageEnglish (US)
Pages (from-to)155-156
Number of pages2
Issue number2
StatePublished - Jan 28 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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