Abstract
The mechanisms by which RNA polymerase moves along DNA during elongation have been difficult to determine experimentally. In this issue of Cell, Bar-Nahum et al. (2005) show that back and forth sliding of RNA polymerase on DNA may be coupled to bending of an α helix, which can alternately occlude and expose the NTP binding site. Transcription factors can regulate elongation by modulating this bending motion.
Original language | English (US) |
---|---|
Pages (from-to) | 155-156 |
Number of pages | 2 |
Journal | Cell |
Volume | 120 |
Issue number | 2 |
DOIs | |
State | Published - Jan 28 2005 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)