Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches

Alexei V. Tumanov, Dmitry V. Kuprash, Julie A. Mach, Sergei A. Nedospasov, Alexander V. Chervonsky

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Organogenesis of Peyer's patches (PP), follicle-associated epithelium, and M cells is impaired in mice lacking B cells. At the same time, lymphotoxin (LT) and TNF are known to be critical for the development of PP. To directly address the function of LT and TNF expressed by B cells in the maintenance of PP structure, we studied the de novo formation of PP in B cell-deficient mice after the transfer of bone marrow from mice with targeted mutations in LT, TNF, or their combinations. We found that although the compartmentalization of T and B cell zones and development of follicular dendritic cells were affected by the lack of B cell-derived LT and TNF, the development of follicle-associated epithelium and M cells in PP was completely independent of LT/TNF production by B cells.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalJournal of Immunology
Volume173
Issue number1
DOIs
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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