Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches

Alexei V. Tumanov, Dmitry V. Kuprash, Julie A. Mach, Sergei A. Nedospasov, Alexander V. Chervonsky

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49 Scopus citations


Organogenesis of Peyer's patches (PP), follicle-associated epithelium, and M cells is impaired in mice lacking B cells. At the same time, lymphotoxin (LT) and TNF are known to be critical for the development of PP. To directly address the function of LT and TNF expressed by B cells in the maintenance of PP structure, we studied the de novo formation of PP in B cell-deficient mice after the transfer of bone marrow from mice with targeted mutations in LT, TNF, or their combinations. We found that although the compartmentalization of T and B cell zones and development of follicular dendritic cells were affected by the lack of B cell-derived LT and TNF, the development of follicle-associated epithelium and M cells in PP was completely independent of LT/TNF production by B cells.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalJournal of Immunology
Issue number1
Publication statusPublished - Jul 1 2004


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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