Lymphoid tissues of "Lethargic" mice

H. C. Dung, E. K. Adrian

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Cellular proliferation in lymphoid tissues of "lethargic" mutant mice and their phenotypically normal littermates was studied by autoradiography with 3H-thymidine at 23 days of age. Both "lethargic" mutants and normal mice were divided into two groups, one of which received sheep red blood cells (SRC) 7 days prior to sacrifice. All mice were given a single injection of 3H-thymidine one hour before sacrifice. The thymic cortex and the splenic red pulp of unimmunized mutant mice have lower labelling indices than those found in normal mice. Immunization with SRC had no effect on the labelling pattern of the thymus. However, in the spleen, immunization with SRC stimulates cell proliferation and increases the number of lightly labelled cells in the white pulp of normal mice but not in "lethargic" mice. Lethargic mice provide a model for studying the relationship between the endocrine system and the immune system.

Original languageEnglish (US)
Pages (from-to)327-337
Number of pages11
JournalDevelopmental and Comparative Immunology
Issue number2
StatePublished - 1978

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology


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