Lymphocyte phenotypes and infection incidence in transfused preterm neonates

S. G. Kutvirt, M. E. Armon, T. L. Simon, S. L. Lewis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The immunomodulating effects of repeated exposure to blood from multiple donors coupled with an immature immune system may predispose the preterm neonate to an increased incidence of infection in his first few months of life. To test this hypothesis, we compared lymphocyte phenotypes, serum IgG concentrations, and histories of infection and rehospitalization in neonates at 4 months corrected age. Two of the study groups were preterm infants who had been transfused with either frozen, deglycerolized or CMV-negative, γ-irradiated blood. Control groups consisted of nontransfused term and preterm infants. There were no differences found in lymphocyte phenotypes or serum IgGconcentrations of controls or transfused infants. No differences were found in the infection or rehospitalization incidence in the transfused infants as compared with nontransfused preterm neonates. We failed to show differences in immune parameters or in infection and rehospitalization rates of the preterm infants analysed. Alongside previously published reports, our data suggest that red cell transfusions have a minimal impact on the immature immune system of the neonate.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalTransfusion Medicine
Volume6
Issue number4
DOIs
StatePublished - 1996

Keywords

  • IgG
  • flow cytometry
  • lymphocyte subsets
  • monoclonal antibodies
  • preterm neonates
  • red cell transfusions

ASJC Scopus subject areas

  • Hematology

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