Lung adenocarcinoma biomarker incidence in hispanic versus non-hispanic white patients

Elizabeth McQuitty, Wei Zhang, Heather Hendrickson, Fermin O. Tio, Jaishree Jagirdar, Randall Olsen, Philip T. Cagle

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Context. - Lung cancer is the leading cause of cancer deaths in the United States and worldwide. Biomarker testing is critical to personalized therapy in lung adenocarcinoma and has been extensively investigated in non- Hispanic whites, Asians, and African Americans. However, little information addresses the underlying genetic changes in lung adenocarcinoma among Hispanic patients in the United States. Objective. - To identify targetable biomarkers other than EGFR and EML4-ALK in Hispanic patients with lung adenocarcinoma. Design. - We tested DNA extracted from 85 lung adenocarcinoma specimens collected from 40 Hispanic and 43 non-Hispanic white patients for previously reported mutations in KRAS, MET, BRAF, mTOR, STAT3, JAK2, PIK3CA, AKT1 through AKT3, and PTEN with a custom Sequenom massARRAY assay (Sequenom, San Diego, California). Results. - Mutations in KRAS were identified in 11 cases (13%; 6 Hispanic [7%], 5 non-Hispanic white [6%]) and had no correlation with sex, age, or smoking history. Mutations in PIK3CA were identified in 2 of the 40 Hispanic patients (5%), including one patient (2.5%) with a concurrent KRAS mutation. The tumors were wild type for all other genes tested. Conclusions. - Targetable biomarkers other than EGFR and EML4-ALK were identified in 7 of the 40 Hispanic patients (18%) and 5 of the 43 non-Hispanic white patients (12%), suggesting a similar mutational frequency. Our highly multiplexed genotyping assay detected actionable mutations in 14% (12 of 83) more patients than would have been identified by EGFR and EML4-ALK testing alone.

Original languageEnglish (US)
Pages (from-to)390-394
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume138
Issue number3
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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    McQuitty, E., Zhang, W., Hendrickson, H., Tio, F. O., Jagirdar, J., Olsen, R., & Cagle, P. T. (2014). Lung adenocarcinoma biomarker incidence in hispanic versus non-hispanic white patients. Archives of Pathology and Laboratory Medicine, 138(3), 390-394. https://doi.org/10.5858/arpa.2013-0225-OA