Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis

Nathan P. Wiederhold, Annette W. Fothergill, Dora I. McCarthy, Amir Tavakkol

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.

Original languageEnglish (US)
Pages (from-to)3553-3555
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number6
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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