Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis

Nathan P. Wiederhold; Annette W. Fothergill; Dora I. McCarthy; Amir Tavakkol

doi:10.1128/AAC.02706-13

Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis

Nathan P. Wiederhold, Annette W. Fothergill, Dora I. McCarthy, Amir Tavakkol

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.

Original language	English (US)
Pages (from-to)	3553-3555
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	6
DOIs	https://doi.org/10.1128/AAC.02706-13
State	Published - Jun 2014

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis",

abstract = "The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.",

author = "Wiederhold, {Nathan P.} and Fothergill, {Annette W.} and McCarthy, {Dora I.} and Amir Tavakkol",

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AU - Fothergill, Annette W.

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AU - Tavakkol, Amir

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