TY - JOUR
T1 - Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis
AU - Wiederhold, Nathan P.
AU - Fothergill, Annette W.
AU - McCarthy, Dora I.
AU - Tavakkol, Amir
PY - 2014/6
Y1 - 2014/6
N2 - The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.
AB - The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.
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U2 - 10.1128/AAC.02706-13
DO - 10.1128/AAC.02706-13
M3 - Article
C2 - 24709260
AN - SCOPUS:84901276889
VL - 58
SP - 3553
EP - 3555
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 6
ER -