LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

Violetta S. Gogoleva; Dmitry V. Kuprash; Sergei I. Grivennikov; Alexei V. Tumanov; Andrey A. Kruglov; Sergei A. Nedospasov

doi:10.3390/cells11121970

LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

Violetta S. Gogoleva
, Dmitry V. Kuprash
, Sergei I. Grivennikov
, Alexei V. Tumanov
, Andrey A. Kruglov
, Sergei A. Nedospasov

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.

Original language	English (US)
Article number	1970
Journal	Cells
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/cells11121970
State	Published - Jun 1 2022

Keywords

Peyer’s patches
TNF
innate lymphoid cells
lymphoid tissue organogenesis
lymphotoxin

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells11121970

Cite this

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title = "LTα, TNF, and ILC3 in Peyer{\textquoteright}s Patch Organogenesis",

abstract = "TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer{\textquoteright}s patch organogenesis.",

keywords = "Peyer{\textquoteright}s patches, TNF, innate lymphoid cells, lymphoid tissue organogenesis, lymphotoxin",

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doi = "10.3390/cells11121970",

language = "English (US)",

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T1 - LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

AU - Gogoleva, Violetta S.

AU - Kuprash, Dmitry V.

AU - Grivennikov, Sergei I.

AU - Tumanov, Alexei V.

AU - Kruglov, Andrey A.

AU - Nedospasov, Sergei A.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.

AB - TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.

KW - Peyer’s patches

KW - TNF

KW - innate lymphoid cells

KW - lymphoid tissue organogenesis

KW - lymphotoxin

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UR - https://www.scopus.com/pages/publications/85132314278#tab=citedBy

U2 - 10.3390/cells11121970

DO - 10.3390/cells11121970

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AN - SCOPUS:85132314278

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 12

M1 - 1970

ER -

LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

Abstract

Keywords

ASJC Scopus subject areas

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