LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

Violetta S. Gogoleva, Dmitry V. Kuprash, Sergei I. Grivennikov, Alexei V. Tumanov, Andrey A. Kruglov, Sergei A. Nedospasov

Research output: Contribution to journalArticlepeer-review


TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.

Original languageEnglish (US)
Article number1970
Issue number12
StatePublished - Jun 1 2022


  • innate lymphoid cells
  • lymphoid tissue organogenesis
  • lymphotoxin
  • Peyer’s patches
  • TNF

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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